Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases.

Autor:	Zhang Z; Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan., Ernst PB; Division of Comparative Pathology and Medicine, Department of Pathology, University of California, San Diego, San Diego, CA, United States.; Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego, San Diego, CA, United States.; Department of Medicine, School of Medicine and Chiba University-University of California San Diego Center for Mucosal Immunology, Allergy and Vaccine (CU-UCSD), University of California, San Diego, San Diego, CA, United States., Kiyono H; Department of Medicine, School of Medicine and Chiba University-University of California San Diego Center for Mucosal Immunology, Allergy and Vaccine (CU-UCSD), University of California, San Diego, San Diego, CA, United States.; Future Medicine Education and Research Organization, Chiba University, Chiba, Japan.; Division of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Human Mucosal Vaccinology, Chiba University Hospital, Chiba, Japan.; HanaVax Inc., Tokyo, Japan.; Mucosal Immunology and Allergy Therapeutics, Institute for Global Prominent Research, Chiba University, Chiba, Japan.; Research Institute of Disaster Medicine, Chiba University, Chiba, Japan., Kurashima Y; Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.; Division of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Mucosal Immunology and Allergy Therapeutics, Institute for Global Prominent Research, Chiba University, Chiba, Japan.; Research Institute of Disaster Medicine, Chiba University, Chiba, Japan.; Institute for Advanced Academic Research, Chiba University, Chiba, Japan.; Empowering Next Generation Allergist/immunologist toward Global Excellence Task Force toward 2030 (ENGAGE)-Task Force, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Sep 14; Vol. 13, pp. 937120. Date of Electronic Publication: 2022 Sep 14 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.937120
Abstrakt:	Mast cells (MCs) are immune cells widely distributed in the body, accompanied by diverse phenotypes and functions. Committed mast cell precursors (MCPs) leave the bone marrow and enter the blood circulation, homing to peripheral sites under the control of various molecules from different microenvironments, where they eventually differentiate and mature. Partly attributable to the unique maturation mechanism, MCs display high functional heterogeneity and potentially plastic phenotypes. High plasticity also means that MCs can exhibit different subtypes to cope with different microenvironments, which we call "the peripheral immune education system". Under the peripheral immune education system, MCs showed a new character from previous cognition in some cases, namely regulation of allergy and inflammation. In this review, we focus on the mucosal tissues, such as the gastrointestinal tract, to gain insights into the mechanism underlying the migration of MCs to the gut or other organs and their heterogeneity, which is driven by different microenvironments. In particular, the immunosuppressive properties of MCs let us consider that positively utilizing MCs may be a new way to overcome inflammatory and allergic disorders. Competing Interests: HK is director and founder of HanaVax Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Zhang, Ernst, Kiyono and Kurashima.)
Databáze:	MEDLINE
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