Insights into the impact of manure on the environmental antibiotic residues and resistance pool.

Autor:	Marutescu LG; Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania.; Research Institute of University of Bucharest, Bucharest, Romania., Jaga M; Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania., Postolache C; Research Institute of University of Bucharest, Bucharest, Romania., Barbuceanu F; Research Institute of University of Bucharest, Bucharest, Romania.; The Institute for Diagnostic and Animal Health (IDSA), Bucharest, Romania.; Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania., Milita NM; Research Institute of University of Bucharest, Bucharest, Romania.; The Institute for Diagnostic and Animal Health (IDSA), Bucharest, Romania.; Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania., Romascu LM; Research Institute of University of Bucharest, Bucharest, Romania.; The Institute for Diagnostic and Animal Health (IDSA), Bucharest, Romania.; Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania., Schmitt H; National Institute for Public Health and the Environment, Bilthoven, Netherlands., de Roda Husman AM; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Sefeedpari P; Wageningen Livestock Research, Wageningen, Netherlands., Glaeser S; Institute for Applied Microbiology Heinrich-Buff-Ring, Justus-Liebig University, Gießen, Germany., Kämpfer P; Institute for Applied Microbiology Heinrich-Buff-Ring, Justus-Liebig University, Gießen, Germany., Boerlin P; Department of Pathobiology, University of Guelph, Guelph, ON, Canada., Topp E; Department of Pathobiology, University of Guelph, Guelph, ON, Canada.; Department of Biology, Agriculture and Agri-Food Canada, University of Western Ontario, London, ON, Canada., Gradisteanu Pircalabioru G; Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania.; Research Institute of University of Bucharest, Bucharest, Romania.; Academy of Romanian Scientists, Bucharest, Romania., Chifiriuc MC; Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania.; Research Institute of University of Bucharest, Bucharest, Romania.; Academy of Romanian Scientists, Bucharest, Romania.; The Romanian Academy, Bucharest, Romania., Popa M; Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania.; Research Institute of University of Bucharest, Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2022 Sep 16; Vol. 13, pp. 965132. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).
DOI:	10.3389/fmicb.2022.965132
Abstrakt:	The intensive use of antibiotics in the veterinary sector, linked to the application of manure-derived amendments in agriculture, translates into increased environmental levels of chemical residues, AR bacteria (ARB) and antibiotic resistance genes (ARG). The aim of this review was to evaluate the current evidence regarding the impact of animal farming and manure application on the antibiotic resistance pool in the environment. Several studies reported correlations between the prevalence of clinically relevant ARB and the amount and classes of antibiotics used in animal farming (high resistance rates being reported for medically important antibiotics such as penicillins, tetracyclines, sulfonamides and fluoroquinolones). However, the results are difficult to compare, due to the diversity of the used antimicrobials quantification techniques and to the different amounts and types of antibiotics, exhibiting various degradation times, given in animal feed in different countries. The soils fertilized with manure-derived products harbor a higher and chronic abundance of ARB, multiple ARG and an enriched associated mobilome, which is also sometimes seen in the crops grown on the amended soils. Different manure processing techniques have various efficiencies in the removal of antibiotic residues, ARB and ARGs, but there is only a small amount of data from commercial farms. The efficiency of sludge anaerobic digestion appears to be dependent on the microbial communities composition, the ARB/ARG and operating temperature (mesophilic vs. thermophilic conditions). Composting seems to reduce or eliminate most of antibiotics residues, enteric bacteria, ARB and different representative ARG in manure more rapidly and effectively than lagoon storage. Our review highlights that despite the body of research accumulated in the last years, there are still important knowledge gaps regarding the contribution of manure to the AMR emergence, accumulation, spread and risk of human exposure in countries with high clinical resistance rates. Land microbiome before and after manure application, efficiency of different manure treatment techniques in decreasing the AMR levels in the natural environments and along the food chain must be investigated in depth, covering different geographical regions and countries and using harmonized methodologies. The support of stakeholders is required for the development of specific best practices for prudent - cautious use of antibiotics on farm animals. The use of human reserve antibiotics in veterinary medicine and of unprescribed animal antimicrobials should be stopped and the use of antibiotics on farms must be limited. This integrated approach is needed to determine the optimal conditions for the removal of antibiotic residues, ARB and ARG, to formulate specific recommendations for livestock manure treatment, storage and handling procedures and to translate them into practical on-farm management decisions, to ultimately prevent exposure of human population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Marutescu, Jaga, Postolache, Barbuceanu, Milita, Romascu, Schmitt, de Roda Husman, Sefeedpari, Glaeser, Kämpfer, Boerlin, Topp, Gradisteanu Pircalabioru, Chifiriuc and Popa.)
Databáze:	MEDLINE
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