Association between parity and markers of inflammation: The multi-ethnic study of atherosclerosis.

Autor:	Ezeigwe A; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Ogunmoroti O; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Minhas AS; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Rodriguez CP; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Kazzi B; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Fashanu OE; Division of Cardiology, Sands Constellation Heart Institute, Rochester Regional Health, Rochester, NY, United States., Osibogun O; Department of Epidemiology, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, United States., Kovell LC; Division of Cardiology, University of Massachusetts Chan School of Medicine, Worchester, MA, United States., Harrington CM; Corrigan's Women's Heart Health Program, Massachusetts General Hospital, Boston, MA, United States., Michos ED; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Sep 14; Vol. 9, pp. 922367. Date of Electronic Publication: 2022 Sep 14 (Print Publication: 2022).
DOI:	10.3389/fcvm.2022.922367
Abstrakt:	Introduction: Multiparity has been associated with increased risk of cardiovascular disease (CVD). Inflammation may be a mechanism linking parity to CVD. We investigated the association between parity and later-life markers of inflammation. Methods: We studied 3,454 female MESA participants aged 45-84, free of CVD, who had data on parity and inflammatory markers. Parity was categorized as 0 (reference), 1-2, 3-4, or ≥5. Linear regression was used to evaluate the association between parity and natural log-transformed levels of fibrinogen, D-dimer, GlycA, high sensitivity C-reactive protein (hsCRP), and interleukin-6 (IL-6). Results: Mean age was 62 ± 10 years. The proportion of women with nulliparity, 1-2, 3-4, and ≥5 live births were 18, 39, 29, and 14%, respectively. There was no association between parity and fibrinogen. Women with grand multiparity (≥5 live births) had 28, 10, and 18% higher levels of hsCRP, IL-6 and D-dimer, respectively, compared to nulliparous women, after adjustment for demographic factors. After additional adjustment for CVD risk factors, women with 1-2 and 3-4 live births had higher hsCRP and women with 1-2 live births had higher GlycA. Conclusion: In this diverse cohort of middle-to-older aged women, we found that higher parity was associated with some inflammatory markers; however, these associations were largely attenuated after adjustment for CVD risk factors. There was no clear dose-response relationship between parity and these inflammatory markers. Future studies are needed to evaluate how inflammation may influence the link between parity and CVD and whether healthy lifestyle/pharmacotherapies targeting inflammation can reduce CVD risk among multiparous women. Clinical Trial Registration: The MESA cohort design is registered at clinicaltrials.gov as follows: https://clinicaltrials.gov/ct2/show/NCT00005487. Competing Interests: Unrelated to this work, Author EM has served on advisory boards for Pfizer, Esperion, Novartis, Novo Nordisk, Bayer, Boehringer Ingelheim, Amarin, and Astra Zeneca. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Ezeigwe, Ogunmoroti, Minhas, Rodriguez, Kazzi, Fashanu, Osibogun, Kovell, Harrington and Michos.)
Databáze:	MEDLINE
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