Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium.

Autor:	de Erausquin GA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA., Snyder H; Alzheimer's Association Chicago Illinois USA., Brugha TS; University of Leicester Leicester UK., Seshadri S; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA., Carrillo M; Alzheimer's Association Chicago Illinois USA., Sagar R; All India Institute of Medical Sciences New Delhi India., Huang Y; Peking University Sixth Hospital Beijing China., Newton C; Medical Sciences Division University of Oxford Oxford UK., Tartaglia C; University of Toronto Toronto Ontario Canada., Teunissen C; Amsterdam UMC Locatie AMC Amsterdam the Netherlands., Håkanson K; Karolinska Institute Solna Sweden., Akinyemi R; University of Ibadan Ibadan Nigeria., Prasad K; All India Institute of Medical Sciences New Delhi India., D'Avossa G; Bangor University Bangor UK., Gonzalez-Aleman G; Pontificia Universidad Católica Argentina Santa María de los Buenos Aires Ciudad Autónoma de Buenos Aires Argentina., Hosseini A; University of Nottingham Nottingham UK., Vavougios GD; University of Thessaly Larissa Greece., Sachdev P; University of New South Wales Sydney New South Wales Australia., Bankart J; University of Leicester Leicester UK., Mors NPO; Aarhus University Aarhus Denmark., Lipton R; Albert Einstein College of Medicine New York New York USA., Katz M; Albert Einstein College of Medicine New York New York USA., Fox PT; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA., Katshu MZ; University of Nottingham Nottingham UK., Iyengar MS; University of Arizona Health Sciences Center Tucson Arizona USA., Weinstein G; University of Haifa Haifa Israel., Sohrabi HR; Centre for Healthy Ageing Murdoch University Murdoch Western Australia Australia., Jenkins R; Institute of Psychiatry King's College London London UK., Stein DJ; University of Cape Town Cape Town South Africa., Hugon J; Université de Paris Cité Faculté de Médecine Paris France., Mavreas V; University of Ioannina Faculty of Medicine Ioannina Greece., Blangero J; Institute of Neuroscience University of Texas Rio Grande Valley Harlingen Texas USA., Cruchaga C; Washington University School of Medicine Saint Louis Missouri USA., Krishna M; Foundation for Research and Advocacy in Mental Health and Viveka Hospital Mysore India., Wadoo O; Hamad Medical Corporation Doha Qatar., Becerra R; University of Western Australia Perth Western Australia Australia., Zwir I; Washington University School of Medicine Saint Louis Missouri USA., Longstreth WT; University of Washington Seattle Washington USA., Kroenenberg G; University of Zurich Zurich Switzerland., Edison P; Imperial College London London UK., Mukaetova-Ladinska E; University of Leicester Leicester UK., Staufenberg E; Hertfordshire Partnership University NHS Foundation Trust Hertfordshire UK., Figueredo-Aguiar M; Fundación de Lucha contra los Trastornos Neurológicos y Psiquiátricos en Minorías (FULTRA) Ciudad Autónoma de Buenos Aires Argentina., Yécora A; Ministerio de Salud de la Provincia de Jujuy San Salvador de Jujuy Argentina., Vaca F; Ministerio de Salud de la Provincia de Jujuy San Salvador de Jujuy Argentina., Zamponi HP; Ministerio de Salud de la Provincia de Jujuy San Salvador de Jujuy Argentina., Re VL; Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione Istituto di Ricovero e Cura a Carattere Scientifico (ISMETT-IRRCS) Palermo Italy., Majid A; Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Srinagar India., Sundarakumar J; Indian Institute of Science Bengaluru India., Gonzalez HM; University of California San Diego San Diego California USA., Geerlings MI; University Medical Center Utrecht Brain Center Rudolf Magnus Utrecht the Netherlands., Skoog I; University of Gothenburg Gothenburg Sweden., Salmoiraghi A; Betsi Cadwaladr University Health Board Bangor UK., Boneschi FM; Università degli Studi di Milano Milan Italy., Patel VN; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Joe and Teresa Long School of Medicine University of Texas Health San Antonio San Antonio Texas USA., Santos JM; Fundación de Lucha contra los Trastornos Neurológicos y Psiquiátricos en Minorías (FULTRA) Ciudad Autónoma de Buenos Aires Argentina., Arroyo GR; Universidad Privada de Santa Cruz de la Sierra Santa Cruz de la Sierra Bolivia., Moreno AC; Universidad de Ciencias Médicas de La Habana La Habana Cuba., Felix P; Complexe Medico-Sociale Maranatha Guilerne Haiti., Gallo C; Laboratorios de Investigación y Desarrollo Facultad de Ciencias y Filosofía Universidad Peruana Cayetano Heredia Lima Perú., Arai H; National Center for Geriatrics and Gerontology Research Institute Department of Regenerative Medicine (NCGG) Obu Japan., Yamada M; Kudanzaka Hospital Tokyo Japan., Iwatsubo T; University of Tokyo Tokyo Japan., Sharma M; University of Washington Seattle Washington USA., Chakraborty N; University of Leicester Leicester UK., Ferreccio C; Pontificia Universidad Catolica de Chile Santiago Chile., Akena D; Makerere University Faculty of Medicine Kampala Uganda., Brayne C; University of Cambridge Cambridge UK., Maestre G; Institute of Neuroscience University of Texas Rio Grande Valley Harlingen Texas USA., Blangero SW; Institute of Neuroscience University of Texas Rio Grande Valley Harlingen Texas USA., Brusco LI; Facultad de Medicina Universidad de Buenos Aires Ciudad Autónoma de Buenos Aires Argentina., Siddarth P; University of California Los Angeles Los Angeles California USA., Hughes TM; Wake Forest School of Medicine Winston-Salem North Carolina USA., Zuñiga AR; University of Cologne Köln Germany., Kambeitz J; University of Cologne Köln Germany., Laza AR; Fundación ACE Alzheimer Center Barcelona Spain., Allen N; Northwestern University Evanston Illinois USA., Panos S; Pacific Neuroscience Institute Santa Monica California USA., Merrill D; Pacific Neuroscience Institute Santa Monica California USA., Ibáñez A; Cognitive Neuroscience Center (CNC) & CONICET Universidad de San Andrés Victoria Argentina.; Global Brain Health Institute (GBHI) University of California San Francisco (UCSF), California, US; & Trinity College Dublin Ireland.; Latin American Brain Health (BrainLat) Universidad Adolfo Ibáñez Santiago Chile., Tsuang D; University of Washington Seattle Washington USA., Valishvili N; Accel Clinical Services Heathrow Florida USA., Shrestha S; University of Mississippi University Hospital Oxford Mississippi USA., Wang S; Indiana University School of Medicine Indianapolis Indiana USA.; University of Warsaw Warsaw Poland., Padma V; All India Institute of Medical Sciences New Delhi India., Anstey KJ; University of New South Wales Sydney New South Wales Australia., Ravindrdanath V; Indian Institute of Science Bengaluru India., Blennow K; University of Gothenburg Gothenburg Sweden., Mullins P; Bangor University Bangor UK., Łojek E; University of Warsaw Warsaw Poland., Pria A; Boston University Boston Massachusetts USA., Mosley TH; University of Mississippi University Hospital Oxford Mississippi USA., Gowland P; University of Nottingham Nottingham UK., Girard TD; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Bowtell R; University of Nottingham Nottingham UK., Vahidy FS; Houston Methodist Neurological Institute Houston Texas USA.; Department of Neurosurgery and the Neurological Institute Houston Methodist Houston Texas USA.; Center for Health Data Science and Analytics Houston Methodist Houston Texas USA.; Department of Population Health Sciences Weill Cornell Medicine New York New York USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Sep 22; Vol. 8 (1), pp. e12348. Date of Electronic Publication: 2022 Sep 22 (Print Publication: 2022).
DOI:	10.1002/trc2.12348
Abstrakt:	Introduction: Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term. Methods: This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results: Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion: The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection. Key Points: The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility.The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease.We provide a framework for current and future studies to be carried out within the Consortium. and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic.The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations. Competing Interests: All authors state that they have no relationships/activities/interests to disclose related to the content of this submission. Author disclosures are available in the supporting information. (© 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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