Association Between Helicobacter pylori Infection and the Risk of Pancreatic Cancer: A Systematic Review Based on Observational Studies.

Autor:	Panthangi V; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Cyril Kurupp AR; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Raju A; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Luthra G; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Shahbaz M; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Almatooq H; Dermatology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Foucambert P; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Esbrand FD; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Zafar S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Khan S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Aug 29; Vol. 14 (8), pp. e28543. Date of Electronic Publication: 2022 Aug 29 (Print Publication: 2022).
DOI:	10.7759/cureus.28543
Abstrakt:	Helicobacter pylori ( H. pylori ) bacterial infection has long been scrutinized as one of the potential risk factors for the development of pancreatic cancer with quite inconsistent and unequivocal data. Little is known about the risk factors involved with this malignancy. In this systematic review, we aimed to examine the relationship between H. pylori infection and pancreatic cancer based on the evidence from the existing observational studies across the world. We searched major electronic databases such as PubMed, MEDLINE, Science Direct, and Cochrane Library. After a careful and thorough screening process, we selected 15 observation studies for this systematic review. Six of 15 studies found a significant association between H. pylori infection and pancreatic cancer. Additionally, four of these studies found a significant relationship between the cytotoxin-associated gene A strain of H. pylori and pancreatic cancer. Based on the evidence from the selected studies, a weak association was observed between H. pylori  infection and cancer of the pancreas, especially in European and Asian populations compared to the North American population. The cross-sectional evidence from the case-control studies only suggests the existence of an association but does not provide substantial evidence of the causative relationship. Further large-scale, prospective cohort studies are warranted in the future to understand this contradictory relationship better. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Panthangi et al.)
Databáze:	MEDLINE
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