Human Immunodeficiency Virus and Cardiac End-Organ Damage in Women: Findings From an Echocardiographic Study Across the United States.

Autor:	Shitole SG; Cardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.; Department of Medicine, University of California San Francisco, San Francisco, California, USA., Lazar JM; Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, USA., Taub CC; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA., Furlani AC; Department of Radiology, Montefiore Health System, Bronx, New York, USA., Konkle-Parker DJ; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Dionne-Odom J; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Fischl MA; Department of Medicine, University of Miami, Miami, Florida, USA., Ofotokun I; Department of Medicine, Emory University, Atlanta, Georgia, USA.; Department of Medicine, Grady Health System, Atlanta, Georgia, USA., Adimora AA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Topper EF; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA., Golzar Y; Division of Cardiology, Cook County Health, Chicago, Illinois, USA., Kassaye SG; Department of Medicine, Georgetown University, Washington, DC, USA., Gustafson D; Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, USA., Anastos K; Department of Radiology, Montefiore Health System, Bronx, New York, USA.; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA., Hanna DB; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA., Xue X; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA., Tien PC; Cardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.; Department of Medicine, University of California San Francisco, San Francisco, California, USA., Kaplan RC; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Kizer JR; Cardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.; Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Jan 13; Vol. 76 (2), pp. 210-219.
DOI:	10.1093/cid/ciac795
Abstrakt:	Background: People with human immunodeficiency virus (HIV) have been reported to have increased risk of clinical and subclinical cardiovascular disease. Existing studies have focused on men and often have been uncontrolled or lacked adequate HIV-negative comparators. Methods: We performed echocardiography in the Women's Interagency HIV Study to investigate associations of HIV and HIV-specific factors with cardiac phenotypes, including left ventricular systolic dysfunction (LVSD), isolated LV diastolic dysfunction (LVDD), left atrial enlargement (LAE), LV hypertrophy (LVH), and increased tricuspid regurgitation velocity (TRV). Results: Of 1654 participants (age 51 ± 9 years), 70% had HIV. Sixty-three (5.4%) women with HIV (WWH) had LVSD; 71 (6.5%) had isolated LVDD. Compared with women without HIV (WWOH), WWH had a near-significantly increased risk of LVSD (adjusted relative risk = 1.69; 95% confidence interval = 1.00 to 2.86; P = .051). No significant association was noted for HIV seropositivity with other phenotypes, but there was a risk gradient for decreasing CD4+ count among WWH that approached or reached significance for isolated LVDD, LAE, and LVH. WWH with CD4+ count <200 cells/mm3 had significantly higher prevalence of LAE, LVH, and high TRV than WWOH. There were no consistent associations for viral suppression or antiretroviral drug exposure. Conclusions: This study suggests that WWH have a higher risk of LVSD compared with sociodemographically similar WWOH, but their risk for isolated LVDD, LAE, LVH, and high TRV is increased only with reduced CD4+ count. Although these findings warrant replication, they support the importance of cardiovascular risk-factor and HIV-disease control for heart disease prevention in this population. (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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