Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats.

Autor: Kim JS; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Kim OH; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Ryu IS; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Kim YH; Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup 56212, Republic of Korea; Department of Environment & Energy, Jeonbuk National University, Jeonju, Jeollabukdo 54896, Republic of Korea; School of Civil, Environmental and Resources-Energy Engineering, Jeonbuk National University, Jeonju, Jeollabukdo 54896, Republic of Korea., Jeon KO; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea; Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 34134, Republic of Korea., Lim LN; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Kim TW; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Sohn S; Department of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea., Kim S; Department of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea., Seo JW; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Choe ES; Department of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea. Electronic address: eschoe@pusan.ac.kr., Jang EY; Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea. Electronic address: eunyoung.jang@kitox.re.kr.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2022 Oct; Vol. 220, pp. 173469. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1016/j.pbb.2022.173469
Abstrakt: Nicotine, the primary addictive substance in tobacco, produces the psychomotor, rewarding, and reinforcing effects of tobacco dependence by stimulating nicotinic acetylcholine receptors (nAChRs) in the brain. The present study determined that α4β2 nAChRs regulate locomotor sensitization by altering dopamine concentration in the nucleus accumbens (NAc) after systemic challenge exposure to whole cigarette smoke condensate (WCSC). Rats were administered subcutaneous injection of WCSC (0.2 mg/kg nicotine/day) for 7 consecutive days and then re-exposed to WCSC after 3 days of withdrawal. Challenge exposure to WCSC significantly increased locomotor activity. This increase was decreased by the subcutaneous injection of the α4β2 nAChR antagonist, DHβE (3 mg/kg), but not by the intraperitoneal injection of the α7 nAChR antagonist, MLA (5 mg/kg). In parallel with a decrease in locomotor activity, blockade of α4β2 nAChRs with DHβE decreased dopamine concentration in the NAc which was elevated by challenge exposure to WCSC. These findings suggest that challenge WCSC leads to the expression of locomotor sensitization by elevating dopamine concentration via stimulation of α4β2 nAChRs expressed in neurons of the NAc in rats.
Competing Interests: Conflicts of interest The authors declare no conflict of interest.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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