A unique Toxoplasma gondii haplotype accompanied the global expansion of cats.

Autor: Galal L; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France. lokmanmagalal@gmail.com., Ariey F; Université de Paris, Institut Cochin, Inserm U1016, Service de Parasitologie Hôpital Cochin, 75014, Paris, France., Gouilh MA; DYNAMICURE U1311 INSERM, Université de Caen Normandie, UNICAEN, UNIROUEN, 14000, Caen, France.; Laboratoire de Virologie, Centre Hospitalo-Universitaire, Avenue Georges Clémenceau, 14000, Caen, France.; Institut de Recherche pour le Développement (IRD), Maladies Infectieuses et vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC) (Université de Montpellier-IRD 224-CNRS 5290), Montpellier, France., Dardé ML; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.; Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Center (BRC), Centre Hospitalier-Universitaire Dupuytren, Limoges, France., Hamidović A; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France., Letourneur F; Plate-Forme Séquençage et Génomique, Institut Cochin, Inserm U1016, Université de Paris, 22 rue Méchain, 75014, Paris, France., Prugnolle F; IRL REHABS, International Research Laboratory REHABS, CNRS-NMU-UCBL, Nelson Mandela University George Campus, George, 6531, South Africa., Mercier A; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France. aurelien.mercier@unilim.fr.; Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Center (BRC), Centre Hospitalier-Universitaire Dupuytren, Limoges, France. aurelien.mercier@unilim.fr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Oct 01; Vol. 13 (1), pp. 5778. Date of Electronic Publication: 2022 Oct 01.
DOI: 10.1038/s41467-022-33556-7
Abstrakt: Toxoplasma gondii is a cyst-forming apicomplexan parasite of virtually all warm-blooded species, with all true cats (Felidae) as definitive hosts. It is the etiologic agent of toxoplasmosis, a disease causing substantial public health burden worldwide. Few intercontinental clonal lineages represent the large majority of isolates worldwide. Little is known about the evolutionary forces driving the success of these lineages, the timing and the mechanisms of their global dispersal. In this study, we analyse a set of 156 genomes and we provide estimates of T. gondii mutation rate and generation time. We elucidate how the evolution of T. gondii populations is intimately linked to the major events that have punctuated the recent history of cats. We show that a unique haplotype, whose length represents only 0.16% of the whole T. gondii genome, is common to all intercontinental lineages and hybrid populations derived from these lineages. This haplotype has accompanied wildcats (Felis silvestris) during their emergence from the wild to domestic settlements, their dispersal in the Old World, and their expansion in the last five centuries to the Americas. The selection of this haplotype is most parsimoniously explained by its role in sexual reproduction of T. gondii in domestic cats.
(© 2022. The Author(s).)
Databáze: MEDLINE
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