Ghrelin level as a biomarker for knee osteoarthritis severity and appearance in HIV + patients.

Autor: Arce-Rosas JI; Servicio de Traumatología y Ortopedia, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., González-Hernández LA; Unidad de VIH, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico., Cabrera-Silva RI; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico., Alvarez-Zavala M; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico., Sánchez-Reyes K; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico., Tafoya Arreguín GA; Servicio de Traumatología y Ortopedia, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., Martinez Ruíz JJ; Servicio de Traumatología y Ortopedia, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., Cerda de la Torre R; Servicio de Radiología e Imagen, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., Ramos-Solano M; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico., Andrade-Villanueva JF; Unidad de VIH, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico. Electronic address: drjandradev@gmail.com.
Jazyk: angličtina
Zdroj: The Knee [Knee] 2022 Dec; Vol. 39, pp. 100-105. Date of Electronic Publication: 2022 Sep 28.
DOI: 10.1016/j.knee.2022.08.005
Abstrakt: Background: Knee Osteoarthritis (KOA) is a multifactorial disease with several mechanisms to promote articular cartilage damage. New molecules, such as ghrelin, have been recently reported to participate in the pathogenesis and progression of KOA. In HIV + patients, arthralgias are the most frequent musculoskeletal manifestations, mainly affecting joints such as the knee. Also, it has been reported that HIV + patients have a reduction of ghrelin even with treatment compared to HIV- patients. However, there is no report in the literature evaluating ghrelin and KOA in the HIV + population. We aimed to evaluate whether serum ghrelin levels can function as a biomarker for OA in HIV + patients.
Methods: We recruited 40 patients, 20 HIV+, and 20 HIV- controls, and grouped as follows: HIV+/KOA+; HIV+/KOA-; HIV-/KOA+; HIV-/KOA-. Clinical features were obtained during clinical visits. Peripheral blood samples were acquired to measure serum ghrelin levels.
Results: The HIV+/KOA + group significantly reduced serum ghrelin levels when compared with the other groups. Comparing the ghrelin levels with the patients' nadir of CD4 + T-cells count, we identified a statistically significant negative correlation in the KOA- group (r = -0.80, P < 0.007). An ROC curve analysis, for the accuracy of ghrelin levels to identified HIV+/KOA + from HIV+/KOA- patients, found an area under the curve of 0.83 (95 % CI 0.65-0.10; P = 0.017), with a cut-off < 4026 pg/mL serum ghrelin levels, with a sensitivity of 0.62 (95 % CI 0.32-0.86), and a specificity of 0.10 (95 % CI 0.59-0.10).
Conclusion: This study shows the potential use of ghrelin levels as a biomarker for KOA in the high-risk HIV population that should be further analyzed.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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