Longitudinal assessment of behaviour in young children undergoing general anaesthesia.

Autor:	Shi Y; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: shi.yu@mayo.edu., Macoun S; Department of Psychology, University of Victoria, Victoria, BC, Canada., Hanson AC; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Schroeder DR; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Kirsch AC; Department of Psychology, NorthShore University Health System, Chicago, IL, USA., Haines KM; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA., Zaccariello MJ; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Warner DO; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Jazyk:	angličtina
Zdroj:	British journal of anaesthesia [Br J Anaesth] 2022 Nov; Vol. 129 (5), pp. 740-746. Date of Electronic Publication: 2022 Sep 29.
DOI:	10.1016/j.bja.2022.08.017
Abstrakt:	Background: Exposure to general anaesthesia in children might increase the risk of long-term behavioural problems. It is unclear if any behavioural changes in the short term after anaesthesia could be associated with long-term problems. The goal of the current study was to evaluate the short-term trajectory of parent-reported behaviour measured by the Behaviour Assessment System for Children, third edition (BASC-3) amongst children aged 2.5-6 yr who underwent general anaesthesia for elective surgery. Methods: Children who were undergoing general anaesthesia for surgery were recruited for assessment of behaviour on two occasions: preoperatively (from 1 week to 1 day before anaesthesia), and 3 months postoperatively. To assess longitudinal changes in the parent-reported behaviour measured by BASC-3, linear mixed models were built with visit number included as a categorical variable and subject-specific random intercepts. Results: Sixty-eight children (37 girls [54%]) were enrolled in the study and completed both assessments. At 3 months after anaesthesia, statistically significant improvements (decrease in T scores) in internalising problems (-2.7 [95% confidence interval -4.2 to -1.1]), anxiety (-2.5 [-4.4 to -0.5]), and somatisation (-3.0 [-5.2 to -0.9]) were found. There were no significant differences in scores between visits for other composites or scales. The pattern of results did not depend upon prior anaesthesia exposure. Conclusions: Anaesthesia for elective surgery in young children was associated with a small decrease in internalising problems but no changes in other areas of behavioural problems when assessed at 3 months postoperatively, including in children with prior exposure to anaesthesia. (Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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