Triggering of ST-elevation myocardial infarction by ultrafine particles in New York: Changes following Tier 3 vehicle introduction.

Autor: Yount CS; Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Boulevard CU420644, Rochester, NY, 14642, USA., Utell MJ; Division of Pulmonary and Critical Care, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box 692, Rochester, NY, 14642, USA; Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box EHSC, Rochester, NY, 14642, USA., Hopke PK; Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Boulevard CU420644, Rochester, NY, 14642, USA; Center for Air and Aquatic Resources Engineering and Sciences, Clarkson University, 8 Clarkson Avenue Box 5708, Potsdam, NY, 13699, USA., Thurston SW; Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box EHSC, Rochester, NY, 14642, USA; Department of Biostatistics and Computational Biology, 265 Crittenden Boulevard CU420630, University of Rochester Medical Center, Rochester, NY, 14642, USA., Lin S; Department of Environmental Health, University at Albany School of Public Health, State University of New York, 1 University Place, Rensselaer, NY, 12144, USA., Ling FS; Division of Cardiology, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Chen Y; Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Boulevard CU420644, Rochester, NY, 14642, USA., Chalupa D; Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box EHSC, Rochester, NY, 14642, USA., Deng X; Department of Environmental Health, University at Albany School of Public Health, State University of New York, 1 University Place, Rensselaer, NY, 12144, USA., Rich DQ; Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Boulevard CU420644, Rochester, NY, 14642, USA; Division of Pulmonary and Critical Care, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box 692, Rochester, NY, 14642, USA; Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box EHSC, Rochester, NY, 14642, USA. Electronic address: david_rich@urmc.rochester.edu.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Jan 01; Vol. 216 (Pt 1), pp. 114445. Date of Electronic Publication: 2022 Sep 29.
DOI: 10.1016/j.envres.2022.114445
Abstrakt: Background: Previously, we found increased rates of ST-elevation myocardial infarction (STEMI) associated with increased ultrafine particle (UFP; <100 nm) concentrations in the previous few hours in Rochester, New York. Relative rates were higher after air quality policies and a recession reduced pollutant concentrations (2014-2016 versus 2005-2013), suggesting PM composition had changed and the same PM mass concentration had become more toxic. Tier 3 light duty vehicles, which should produce less primary organic aerosols and oxidizable gaseous compounds, likely making PM less toxic, were introduced in 2017. Thus, we hypothesized we would observe a lower relative STEMI rate in 2017-2019 than 2014-2016.
Methods: Using STEMI events treated at the University of Rochester Medical Center (2014-2019), UFP and other pollutants measured in Rochester, a case-crossover design, and conditional logistic regression models, we estimated the rate of STEMI associated with increased UFP and other pollutants in the previous hours and days in the 2014-2016 and 2017-2019 periods.
Results: An increased rate of STEMI was associated with each 3111 particles/cm 3 increase in UFP concentration in the previous hour in 2014-2016 (lag hour 0: OR = 1.22; 95% CI = 1.06, 1.39), but not in 2017-2019 (OR = 0.94; 95% CI = 0.80, 1.10). There were similar patterns for black carbon, UFP 11-50nm , and UFP 51-100nm . In contrast, increased rates of STEMI were associated with each 0.6 ppb increase in SO 2 concentration in the previous 120 h in both periods (2014-2016: OR = 1.26, 95% CI = 1.03, 1.55; 2017-2019: OR = 1.21, 95% CI = 0.87, 1.68).
Conclusions: Greater rates of STEMI were associated with short term increases in concentrations of UFP and other motor vehicle related pollutants before Tier 3 introduction (2014-2016), but not afterwards (2017-2019). This change may be due to changes in PM composition after Tier 3 introduction, as well as to increased exposure misclassification and greater underestimation of effects from 2017 to 2019.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: David Rich reports financial support was provided by New York State Energy Research Development Authority. David Rich reports financial support was provided by National Institute of Environmental Health Sciences. David Rich reports a relationship with US Environmental Protection Agency that includes: consulting or advisory.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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