Neisseria gonorrhoeae: DNA Repair Systems and Their Role in Pathogenesis.

Autor: Savitskaya VY; Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Monakhova MV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia., Iakushkina IV; Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Borovikova II; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119991, Russia., Kubareva EA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. kubareva@belozersky.msu.ru.
Jazyk: angličtina
Zdroj: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2022 Sep; Vol. 87 (9), pp. 965-982.
DOI: 10.1134/S0006297922090097
Abstrakt: Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative agent of gonorrhea, a sexually transmitted infection. The bacterium uses various approaches for adapting to environmental conditions and multiplying efficiently in the human body, such as regulation of expression of gene expression of surface proteins and lipooligosaccharides (e.g., expression of various forms of pilin). The systems of DNA repair play an important role in the bacterium ability to survive in the host body. This review describes DNA repair systems of N. gonorrhoeae and their role in the pathogenicity of this bacterium. A special attention is paid to the mismatch repair system (MMR) and functioning of the MutS and MutL proteins, as well as to the role of these proteins in regulation of the pilin antigenic variation of the N. gonorrhoeae pathogen.
Databáze: MEDLINE
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