Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APP NL-G-F mouse model of Alzheimer disease following long-term voluntary exercise.

Autor: Mehla J; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.; Present address: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA., Deibel SH; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.; Present address: Department of Psychology, University of New Brunswick, POB 4400, Fredericton, NB, E3B 3A1, Canada., Karem H; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada., Hossain S; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada., Lacoursiere SG; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada., Sutherland RJ; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada., Mohajerani MH; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada. mohajerani@uleth.ca., McDonald RJ; Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada. r.mcdonald@uleth.ca.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Sep 30; Vol. 14 (1), pp. 143. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1186/s13195-022-01085-6
Abstrakt: Background: An active lifestyle is associated with improved cognitive functions in aged people and may prevent or slow down the progression of various neurodegenerative diseases including Alzheimer's disease (AD). To investigate these protective effects, male APP NL-G-F mice were exposed to long-term voluntary exercise.
Methods: Three-month-old AD mice were housed in a cage supplemented with a running wheel for 9 months for long-term exercise. At the age of 12 months, behavioral tests were completed for all groups. After completing behavioral testing, their brains were assessed for amyloid pathology, microgliosis, and cholinergic cells.
Results: The results showed that APP NL-G-F mice allowed to voluntarily exercise showed an improvement in cognitive functions. Furthermore, long-term exercise also improved anxiety in APP NL-G-F mice as assessed by measuring thigmotaxis in the Morris water task. We also found reductions in amyloid load and microgliosis, and a preservation of cholinergic cells in the brain of APP NL-G-F mice allowed to exercise in their home cages. These profound reductions in brain pathology associated with AD are likely responsible for the observed improvement of learning and memory functions following extensive and regular exercise.
Conclusion: These findings suggest the potential of physical exercise to mitigate the cognitive deficits in AD.
(© 2022. The Author(s).)
Databáze: MEDLINE
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