Lipidic profiles of patients starting peritoneal dialysis suggest an increased cardiovascular risk beyond classical dyslipidemia biomarkers.

Autor: Lluesa JH; Metabolomics Unit, Health Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain., López-Romero LC; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain. luiscarloslopezromero@gmail.com., Monzó JJB; Department of Nephrology and Renal Transplantation, Hospital Clínic, Carrer de Villarroel 170, 08036, Barcelona, Spain. jjbroseta@clinic.cat., Marugán MR; Metabolomics Unit, Health Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain., Boyano IV; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain., Rodríguez-Espinosa D; Department of Nephrology and Renal Transplantation, Hospital Clínic, Carrer de Villarroel 170, 08036, Barcelona, Spain., Gómez-Bori A; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain., Orient AS; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain., Such RD; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain., Perez PS; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain., Jaras JH; Department of Nephrology, Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, 46026, Valencia, Spain.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Sep 30; Vol. 12 (1), pp. 16394. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1038/s41598-022-20757-9
Abstrakt: Patients on peritoneal dialysis (PD) have an increased risk of cardiovascular disease (CVD) and an atherogenic lipid profile generated by exposure to high glucose dialysis solutions. In the general population, the reduction of classic lipids biomarkers is associated with improved clinical outcomes; however, the same results have not been seen in PD population, a lack of data this study aims to fulfill. Single-center prospective observational study of a cohort of CKD patients who started renal replacement therapy with continuous ambulatory peritoneal dialysis. The differences in the lipid profile and analytical variables before and 6 months after the start of peritoneal dialysis were analyzed. Samples were analyzed on an Ultra-Performance Liquid Chromatography system. Thirty-nine patients were enrolled in this study. Their mean age was 57.9 ± 16.3 years. A total of 157 endogenous lipid species of 11 lipid subclasses were identified. There were significant increases in total free fatty acids (p < 0.05), diacylglycerides (p < 0.01), triacylglycerides, (p < 0.01), phosphatidylcholines (p < 0.01), phosphatidylethanolamines (p < 0.01), ceramides (p < 0.01), sphingomyelins (p < 0.01), and cholesterol esters (p < 0.01) from baseline to 6 months. However, there were no differences in the classical lipid markers, neither lysophosphatidylcholines, monoacylglycerides, and sphingosine levels. 6 months after the start of the technique, PD patients present changes in the lipidomic profile beyond the classic markers of dyslipidemia.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje