[Biochemical and ultrastructural changes in the brain of the rat exposed to the cerebrospinal fluid of schizophrenics].

Autor: Vilkov GA, Bardakhch'ian EA, Kiroĭ RI, Stepanenko EM, Siletskiĭ OIa
Jazyk: ruština
Zdroj: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) [Zh Nevropatol Psikhiatr Im S S Korsakova] 1987; Vol. 87 (5), pp. 735-8.
Abstrakt: Using biochemical and ultrastructural methods of examination, the authors studied the brain of rats following the intracysternal injection of spinal fluid from schizophrenic patients. The elicited disorders of the ultrastructure of neurons of the medulla oblongata as well as alterations in the content of lipid peroxidation products, gangliosides and cerebrosides were directly correlated with disorders identified in the brain of schizophrenic patients. It was concluded on the basis of the results obtained that marked neurotoxic properties of schizophrenics' cerebral fluid appeared to be explained by the presence of antibodies to brain antigens.
Databáze: MEDLINE