Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark.

Autor: Lyngse FP; Department of Economics & Center for Economic Behavior and Inequality, University of Copenhagen, Copenhagen, Denmark. fpl@econ.ku.dk.; Danish Ministry of Health, Copenhagen, Denmark. fpl@econ.ku.dk.; Statens Serum Institut, Copenhagen, Denmark. fpl@econ.ku.dk., Kirkeby CT; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Denwood M; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christiansen LE; Department of Applied Mathematics and Computer Science; Dynamical Systems, Technical University of Denmark, Kgs. Lyngby, Denmark., Mølbak K; Statens Serum Institut, Copenhagen, Denmark.; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Møller CH; Statens Serum Institut, Copenhagen, Denmark., Skov RL; Statens Serum Institut, Copenhagen, Denmark., Krause TG; Statens Serum Institut, Copenhagen, Denmark., Rasmussen M; Statens Serum Institut, Copenhagen, Denmark., Sieber RN; Statens Serum Institut, Copenhagen, Denmark., Johannesen TB; Statens Serum Institut, Copenhagen, Denmark., Lillebaek T; Statens Serum Institut, Copenhagen, Denmark.; Global Health Section, University of Copenhagen, Copenhagen, Denmark., Fonager J; Statens Serum Institut, Copenhagen, Denmark., Fomsgaard A; Statens Serum Institut, Copenhagen, Denmark., Møller FT; Statens Serum Institut, Copenhagen, Denmark., Stegger M; Statens Serum Institut, Copenhagen, Denmark., Overvad M; Statens Serum Institut, Copenhagen, Denmark., Spiess K; Statens Serum Institut, Copenhagen, Denmark., Mortensen LH; Statistics Denmark, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Sep 30; Vol. 13 (1), pp. 5760. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1038/s41467-022-33498-0
Abstrakt: SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 and BA.2 within households. Among 22,678 primary cases, we identified 17,319 secondary infections among 50,588 household contacts during a 1-7 day follow-up. The secondary attack rate (SAR) was 29% and 39% in households infected with Omicron BA.1 and BA.2, respectively. BA.2 was associated with increased susceptibility of infection for unvaccinated household contacts (Odds Ratio (OR) 1.99; 95%-CI 1.72-2.31), fully vaccinated contacts (OR 2.26; 95%-CI 1.95-2.62) and booster-vaccinated contacts (OR 2.65; 95%-CI 2.29-3.08), compared to BA.1. We also found increased infectiousness from unvaccinated primary cases infected with BA.2 compared to BA.1 (OR 2.47; 95%-CI 2.15-2.84), but not for fully vaccinated (OR 0.66; 95%-CI 0.57-0.78) or booster-vaccinated primary cases (OR 0.69; 95%-CI 0.59-0.82). Omicron BA.2 is inherently more transmissible than BA.1. Its immune-evasive properties also reduce the protective effect of vaccination against infection, but do not increase infectiousness of breakthrough infections from vaccinated individuals.
(© 2022. The Author(s).)
Databáze: MEDLINE
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