Vaccine-associated paralytic poliomyelitis in a child: fast transformation from Sabin-like virus to vaccine-derived poliovirus triggered an epidemiological response in two countries of the European region.

Autor:	Ivanova OE; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia; Institute for Translation Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia. Electronic address: ivanova_oe@chumakovs.su., Kozlovskaya LI; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia; Institute for Translation Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia., Eremeeva TP; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia., Shakaryan AK; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia., Ivanov AP; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia., Baykova OY; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia., Krasota AY; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia; Belozersky Institute of Physical-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Shustova EY; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia., Mustafina AN; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia., Morozova NS; Federal Centre of Hygiene and Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), Moscow, Russia., Bobokhonova MS; National Center for Immunoprophylaxis, Tajikistan Ministry of Health, Dushanbe, Tajikistan., Deshevoi SE; World Health Organization office in the Russian Federation, Moscow, Russian Federation., Ishmukhametov AA; Chumakov Federal Scientific Centre for Research and Development of Immune-and-Biological Products of the Russian Academy of Science (Institute of poliomyelitis), Moscow, Russia; Institute for Translation Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2022 Dec; Vol. 125, pp. 35-41. Date of Electronic Publication: 2022 Sep 28.
DOI:	10.1016/j.ijid.2022.09.034
Abstrakt:	Objectives: The detection of a vaccine-derived poliovirus (VDPV) requires an epidemiological assessment and response. Using repeated stool sampling from a child who is immunocompetent and was vaccinated against poliomyelitis with acute flaccid paralysis, a case of an extremely rapid evolution of Sabin-like poliovirus (PV) type 3 was traced in the child's body. Methods: The case was independently identified in two countries-Tajikistan and Russia. Stool samples for the study were also independently collected in two countries on different days from the onset of paralysis. Virological, serological, and molecular methods; full genome Sanger; and high-throughput sequencing were performed to characterize isolates. Results: PV isolates from samples collected on days 2, 3, and 14 contained eight, seven, and seven mutations in the VP1-coding region, respectively, and were classified as Sabin-like PV type 3. The isolates from samples collected on days 15 and 18 had 11 mutations and were classified as vaccine-derived PVs, which required an epidemiological response in the two countries. Conclusion: The results indicate the need to continue acute flaccid paralysis surveillance, maintain high vaccination coverage, and develop and introduce new effective, genetically stable PV vaccines. Competing Interests: Declaration of Competing Interest The authors have no competing interests to declare. (Copyright © 2022. Published by Elsevier Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu