| Autor: |
Zarzar TR; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Rosen DL; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Mayo JP 3rd; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., O'Connell MG; North Carolina Department of Public Safety - Prisons, Raleigh, North Carolina, USA., Catlett TL; North Carolina Department of Public Safety - Prisons, Raleigh, North Carolina, USA., Reed JG; North Carolina Department of Public Safety - Prisons, Raleigh, North Carolina, USA., Williams JB; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Sheitman BB; North Carolina Department of Public Safety - Prisons, Raleigh, North Carolina, USA. |
| Abstrakt: |
This retrospective review examines clozapine's effects on treatment-refractory incarcerated individuals ( N = 23) with recurrent thoughts of self-harm and/or self-injurious behavior. Emergent suicide risk assessments and days on suicide watch were assessed for the 3 months pre- and post-clozapine treatment. Total suicide assessments fell from 73 pre- to 14 post-clozapine, with a median of 2 assessments (interquartile range [IQR]: 1,5) pre-clozapine compared with 0 (IQR: 0,1) post-clozapine ( p < 0.0001). Total days on suicide watch decreased from 104 days pre- to 32 post-clozapine, with a median of 3 days (IQR: 0,9) pre-clozapine compared with 0 (IQR: 0,0) post-clozapine ( p = 0.0012). Emergency room visits and medical hospitalizations decreased substantially for all months of treatment. Clozapine treatment was associated with marked reductions in self-injurious thoughts and behaviors in high-risk incarcerated individuals. |
