Engineering multicellular living systems-a Keystone Symposia report.

Autor: Cable J; PhD Science Writer, New York, New York, USA., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Parker KK; Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA., Hughes AJ; Department of Bioengineering, School of Engineering and Applied Science and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Goodwin K; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA., Mummery CL; Department of Anatomy and Embryology and LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, the Netherlands., Kamm RD; Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Engle SJ; Translational Biology, Biogen, Cambridge, Massachusetts, USA., Tagle DA; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA., Boj SF; Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands., Stanton AE; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Morishita Y; Laboratory for Developmental Morphogeometry, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.; Precursory Research for Embryonic Science and Technology (PRESTO) Program, Japan Science and Technology Agency, Kawaguchi, Japan., Kemp ML; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Norfleet DA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., May EE; Department of Biomedical Engineering and HEALTH Research Institute, University of Houston, Houston, Texas, USA.; Wisconsin Institute of Discovery and Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Lu A; Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.; Draper Laboratory, Biological Engineering Division, Cambridge, Massachusetts, USA., Bashir R; Beckman Institute for Advanced Science and Technology, Urbana, Illinois, USA.; Holonyak Micro & Nanotechnology Laboratory, Department of Electrical and Computer Engineering and Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA., Feinberg AW; Department of Biomedical Engineering and Department of Materials Science & Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA., Hull SM; Department of Chemical Engineering, Stanford University, Stanford, California, USA., Gonzalez AL; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA., Blatchley MR; BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado, USA., Montserrat Pulido N; Institute for Bioengineering of Catalonia, Catalonia, Spain., Morizane R; Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts, USA., McDevitt TC; The Gladstone Institutes and Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA., Mishra D; Department of Biological Engineering, Synthetic Biology Center, Cambridge, Massachusetts, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Mulero-Russe A; Parker H. Petit Institute for Bioengineering and Bioscience and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2022 Dec; Vol. 1518 (1), pp. 183-195. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1111/nyas.14896
Abstrakt: The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3-6, 2022, experts in the field met at the Keystone symposium "Engineering Multicellular Living Systems" to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium "Organoids as Tools for Fundamental Discovery and Translation".
(© 2022 New York Academy of Sciences.)
Databáze: MEDLINE
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