Characteristics of patients with hepatocellular carcinoma: A multicenter study.

Autor:	Guzelbulut F; Department of Gastroenterology, University of Health Sciences Turkey, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkiye., Karaogullarindan U; Department of Gastroenterology, Çukurova University, Faculty of Medicine, Adana, Turkiye., Akkiz H; Department of Gastroenterology, Çukurova University, Faculty of Medicine, Adana, Turkiye., Altintas E; Department of Gastroenterology, Mersin University, Faculty of Medicine, Mersin, Turkiye., Demirtas CO; Department of Gastroenterology, Marmara University, Faculty of Medicine, Istanbul, Turkiye., Bahadir O; Department of Gastroenterology, University of Health Sciences Turkey, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkiye., Keklikkiran C; Department of Gastroenterology, Marmara University, Faculty of Medicine, Istanbul, Turkiye., Yildirim AE; Department of Gastroenterology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkiye., Gumussoy M; Department of Gastroenterology, Ankara University, Faculty of Medicine, Ankara, Turkiye., Balci HR; Department of Gastroenterology, Mersin University, Faculty of Medicine, Mersin, Turkiye., Gokcen P; Department of Gastroenterology, University of Health Sciences Turkey, Umraniye Training and Research Hospital, Istanbul, Turkiye., Gokce DT; Department of Gastroenterology, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkiye., Simsek C; Department of Gastroenterology, Hacettepe University, Faculty of Medicine, Ankara, Turkiye., Turan I; Department of Gastroenterology, Ege University, Faculty of Medicine, Izmir, Turkiye., Can G; Department of Gastroenterology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkiye., Gokbulut V; Department of Gastroenterology, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkiye., Yaras S; Department of Gastroenterology, Mersin University, Faculty of Medicine, Mersin, Turkiye., Adali G; Department of Gastroenterology, University of Health Sciences Turkey, Umraniye Training and Research Hospital, Istanbul, Turkiye., Akdogan RA; Department of Gastroenterology, Recep Tayyip Erdogan University, Faculty of Medicine, Rize, Turkiye., Avcioglu U; Department of Gastroenterology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkiye., Demir M; Department of Gastroenterology, Mustafa Kemal University, Faculty of Medicine, Hatay, Turkiye., Doganay HL; Department of Gastroenterology, University of Health Sciences Turkey, Umraniye Training and Research Hospital, Istanbul, Turkiye., Vatansever S; Department of Gastroenterology, Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkiye., Sumer H; Department of Gastroenterology, Ankara University, Faculty of Medicine, Ankara, Turkiye., Dilber F; Department of Gastroenterology, Marmara University, Faculty of Medicine, Istanbul, Turkiye., Kayhan MA; Department of Gastroenterology, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkiye., Balaban HY; Department of Gastroenterology, Hacettepe University, Faculty of Medicine, Ankara, Turkiye., Simsek H; Department of Gastroenterology, Hacettepe University, Faculty of Medicine, Ankara, Turkiye., Ozdogan OC; Department of Gastroenterology, Marmara University, Faculty of Medicine, Istanbul, Turkiye., Akarca US; Department of Gastroenterology, Ege University, Faculty of Medicine, Izmir, Turkiye., Karasu Z; Department of Gastroenterology, Ege University, Faculty of Medicine, Izmir, Turkiye., Gunsar F; Department of Gastroenterology, Ege University, Faculty of Medicine, Izmir, Turkiye., Idilman R; Department of Gastroenterology, Ankara University, Faculty of Medicine, Ankara, Turkiye.
Jazyk:	angličtina
Zdroj:	Hepatology forum [Hepatol Forum] 2022 Sep 23; Vol. 3 (3), pp. 71-76. Date of Electronic Publication: 2022 Sep 23 (Print Publication: 2022).
DOI:	10.14744/hf.2022.2022.0028
Abstrakt:	Background and Aim: The aim of the present study was to examine the etiology of hepatocellular carcinoma (HCC) by underlying cause and determine the characteristics and clinical features of patients with HCC. Materials and Methods: The study comprised 1802 HCC patients diagnosed and followed up by Liver Diseases Outpatient Clinics in 14 tertiary centers in Turkey between 2001 and 2020. Results: The mean age was 62.3±10.7 years, and 78% of them were males. Of the patients, 82% had cirrhosis. Hepatitis B virus (HBV) infection was the most common etiology (54%), followed by hepatitis C virus (HCV) infection (19%) and nonalcoholic fatty liver disease (NAFLD) (10%). Of the patients, 56% had a single lesion. Macrovascular invasion and extrahepatic spread were present in 15% and 12% of the patients, respectively. The median serum alpha-fetoprotein level was 25.4 ng/mL. In total, 39% of the patients fulfilled the Milan Criteria. When we compared the characteristics of patients diagnosed before and after January 2016, the proportion of NAFLD-related HCC cases increased after 2016, from 6.6% to 13.4%. Conclusion: Chronic HBV and HCV infections remain the main causes of HCC in Turkey. The importance of NAFLD as a cause of HCC is increasing. Competing Interests: The authors have no conflict of interest to declare. (© Copyright 2022 by Hepatology Forum.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu