Synthesis of Esters Containing Cinnamoyl Motif with Potential Larvicide Action: A Computational, Ecotoxicity and in Vitro Cytotoxicity Assessments.

Autor: Dos Santos Correia PR; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., de Carvalho CM; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., da Silva Cunha CR; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., da Silva RAS; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., de Oliveira Lima M; Institute of Biological and Heath Science, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., França SB; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., de Oliveira Barreto E; Institute of Biological and Heath Science, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., Tonholo J; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil., da Paz Lima DJ; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Avenida Lourival de Melo Mota, 57070-970, Maceio, AL, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2022 Nov; Vol. 19 (11), pp. e202200256. Date of Electronic Publication: 2022 Oct 20.
DOI: 10.1002/cbdv.202200256
Abstrakt: An increasing morbidity and mortality rate has been related to arboviruses transmitted by Aedes aegypti. Compounds with cinnamoyl moiety represent an alternative against mosquitos, considering their larvicidal activity. This study aimed to assess the larvicidal activity of cinnamic ester derivates against Aedes aegypti larvae, along with evaluating their toxicity effect to assess its safety as a larvicide. Ethyl cinnamate demonstrated larvicidal activity (LC 50 =48.59 μg/mL). Morphological changes in larvae were detected, as a degenerative response in the thorax. Through molecular docking, the molecular binding mode between 3b, 3c, and acetylcholinesterase showed strong hydrogen bond interactions. Preliminary in vitro cell viability revealed the non-cytotoxicity of 3c. Ecotoxicity results indicated a sensitivity of Artemia salina to cinnamic esters. The phytotoxicity bioassays show potential for cinnamic compounds to enhance germination and root development. These findings suggest that compound 3c is more suitable as a larvicide since it demonstrated low toxicity.
(© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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