Neurodevelopmental outcomes of extremely preterm infants fed an exclusive human milk-based diet versus a mixed human milk + bovine milk-based diet: a multi-center study.

Autor: Hair AB; Department of Pediatrics, Division of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. abhair@texaschildrens.org., Patel AL; Department of Pediatrics, Neonatology, Rush University Medical Center, Chicago, IL, USA., Kiechl-Kohlendorfer U; Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria., Kim JH; Department of Pediatrics, Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Schanler RJ; Department of Pediatrics, Neonatal Perinatal Medicine, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY, USA., Hawthorne KM; Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX, USA., Itriago E; Department of Pediatrics, Division of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA., Abrams SA; Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX, USA., Blanco CL; Department of Pediatrics, University of Texas Health Science Center, San Antonio, TX, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2022 Nov; Vol. 42 (11), pp. 1485-1488. Date of Electronic Publication: 2022 Sep 28.
DOI: 10.1038/s41372-022-01513-3
Abstrakt: Objective: The objective of this multi-center study was to compare, in infants ≤1250 g birth weight (BW) with neurodevelopmental assessment at 18-22 months of corrected age (CA), whether their neurodevelopmental outcomes differed based on exposure to an exclusive human milk-based (HUM) or to a bovine milk-based fortifier and/or preterm formula (BOV).
Study Design: Retrospective multi-center cohort study of infants undergoing neurodevelopmental assessment as to whether HUM or BOV exposure related to differences in outcomes of infants at 18-22 months CA, using the Bayley Scales of Infant Development III (BSID-III). BSID-III cognitive, language, and motor scores were adjusted for BW, sex, study site, and necrotizing enterocolitis.
Results: 252 infants from 6 centers were included. BSID-III cognitive scores were higher in the HUM group (96.5 ± 15.1 vs 89.6 ± 14.1, adjusted p = 0.0001). Mean BSID-III language scores were 85.5 ± 15.0 in HUM and 82.2 ± 14.1 in BOV (adjusted p = 0.09). Mean BSID-III motor scores were 92.9 ± 11.7 in HUM and 91.4 ± 14.6 in BOV (adjusted p = 0.32).
Conclusion: In this cohort of infants undergoing neurodevelopmental assessment, infants receiving HUM diet had significantly higher cognitive BSID-III scores at 18-22 months CA. Further investigation is needed of this potential for HUM to positively influence infant cognitive outcomes.
(© 2022. The Author(s).)
Databáze: MEDLINE
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