Increased myelination plays a central role in white matter neuroplasticity.

Autor: Kirby ED; BrainNET, Health and Technology District, Vancouver, Canada; Faculty of Individualized Interdisciplinary Studies, Simon Fraser University, Burnaby, Canada., Frizzell TO; BrainNET, Health and Technology District, Vancouver, Canada; Faculty of Applied Sciences, Simon Fraser University, Burnaby, Canada., Grajauskas LA; Department of Biomedical, Physiology, and Kinesiology, Simon Fraser University, Burnaby, Canada; Cumming School of Medicine, University of Calgary, Calgary, Canada., Song X; Department of Biomedical, Physiology, and Kinesiology, Simon Fraser University, Burnaby, Canada; Department of Research and Evaluation Services and Surrey Memorial Hospital, Fraser Health Authority, Surrey, Canada., Gawryluk JR; Department of Psychology, University of Victoria, Victoria, Canada., Lakhani B; BrainNET, Health and Technology District, Vancouver, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., Boyd L; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., D'Arcy RCN; BrainNET, Health and Technology District, Vancouver, Canada; Faculty of Applied Sciences, Simon Fraser University, Burnaby, Canada; Department of Research and Evaluation Services and Surrey Memorial Hospital, Fraser Health Authority, Surrey, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. Electronic address: rdarcy@sfu.ca.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2022 Nov; Vol. 263, pp. 119644. Date of Electronic Publication: 2022 Sep 25.
DOI: 10.1016/j.neuroimage.2022.119644
Abstrakt: White matter (WM) neuroplasticity in the human brain has been tracked non-invasively using advanced magnetic resonance imaging techniques, with increasing evidence for improved axonal transmission efficiency as a central mechanism. The current study is the culmination of a series of studies, which characterized the structure-function relationship of WM transmission efficiency in the cortico-spinal tract (CST) during motor learning. Here, we test the hypothesis that increased transmission efficiency is linked directly to increased myelination using myelin water imaging (MWI). MWI was used to evaluate neuroplasticity-related improvements in the CST. The MWI findings were then compared to diffusion tensor imaging (DTI) results, with the secondary hypothesis that radial diffusivity (RD) would have a stronger relationship than axial diffusivity (AD) if the changes were due to increased myelination. Both MWI and RD data showed the predicted pattern of significant results, strongly supporting that increased myelination plays a central role in WM neuroplasticity.
Competing Interests: Declaration of Competing Interest The authors have no relevant financial or non-financial interests to disclose.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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