Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays.

Autor: Russman SM; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Cleary DR; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Neurosurgery, University of California, San Diego, La Jolla, CA 92093, USA., Tchoe Y; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Bourhis AM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Stedelin B; Department of Neurosurgery, Oregon Health & Science University, Portland, OR 97239, USA., Martin J; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Neurosurgery, University of California, San Diego, La Jolla, CA 92093, USA., Brown EC; Department of Neurosurgery, Oregon Health & Science University, Portland, OR 97239, USA., Zhang X; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA 92093, USA., Kawamoto A; Department of Neurosurgery, Oregon Health & Science University, Portland, OR 97239, USA., Ryu WHA; Department of Neurosurgery, Oregon Health & Science University, Portland, OR 97239, USA., Raslan AM; Department of Neurosurgery, Oregon Health & Science University, Portland, OR 97239, USA., Ciacci JD; Department of Neurosurgery, University of California, San Diego, La Jolla, CA 92093, USA., Dayeh SA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Jazyk: angličtina
Zdroj: Science translational medicine [Sci Transl Med] 2022 Sep 28; Vol. 14 (664), pp. eabq4744. Date of Electronic Publication: 2022 Sep 28.
DOI: 10.1126/scitranslmed.abq4744
Abstrakt: Intraoperative neuromonitoring (IONM) is a widely used practice in spine surgery for early detection and minimization of neurological injury. IONM is most commonly conducted by indirectly recording motor and somatosensory evoked potentials from either muscles or the scalp, which requires large-amplitude electrical stimulation and provides limited spatiotemporal information. IONM may inform of inadvertent events during neurosurgery after they occur, but it does not guide safe surgical procedures when the anatomy of the diseased spinal cord is distorted. To overcome these limitations and to increase our understanding of human spinal cord neurophysiology, we applied a microelectrode array with hundreds of channels to the exposed spinal cord during surgery and resolved spatiotemporal dynamics with high definition. We used this method to construct two-dimensional maps of responsive channels and define with submillimeter precision the electrophysiological midline of the spinal cord. The high sensitivity of our microelectrode array allowed us to record both epidural and subdural responses at stimulation currents that are well below those used clinically and to resolve postoperative evoked potentials when IONM could not. Together, these advances highlight the potential of our microelectrode arrays to capture previously unexplored spinal cord neural activity and its spatiotemporal dynamics at high resolution, offering better electrophysiological markers that can transform IONM.
Databáze: MEDLINE
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