The power of a novel combined anticancer therapy: challenge and opportunity of micotherapy in the treatment of Glioblastoma Multiforme.

Autor: Gaiaschi L; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy. Electronic address: ludovica.gaiaschi@unipv.it., Roda E; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy; Laboratory of Clinical and Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, ICS Maugeri Spa, IRCCS, 27100 Pavia, Italy. Electronic address: elisa.roda@unipv.it., Favaron C; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy. Electronic address: cristina.favaron01@universitadipavia.it., Gola F; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy. Electronic address: federica.gola01@universitadipavia.it., Gabano E; Department of Sciences and Technological Innovation (DiSIT), University of Piemonte Orientale 'A. Avogadro', Viale Teresa Michel 11, 15121 Alessandria, Italy. Electronic address: elisabetta.gabano@uniupo.it., Ravera M; Department of Sciences and Technological Innovation (DiSIT), University of Piemonte Orientale 'A. Avogadro', Viale Teresa Michel 11, 15121 Alessandria, Italy. Electronic address: mauro.ravera@uniupo.it., Rossi P; Laboratory of Neurophysiology and Integrated Physiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy. Electronic address: paola.rossi@unipv.it., Bottone MG; Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy. Electronic address: mariagrazia.bottone@unipv.it.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Nov; Vol. 155, pp. 113729. Date of Electronic Publication: 2022 Sep 24.
DOI: 10.1016/j.biopha.2022.113729
Abstrakt: Glioblastoma (GBM) is the most common and mortal primary brain tumor in human. After standard therapies, that include surgical resection followed by radiotherapy and chemotherapy, it is difficult to completely remove the tumor and the development of relapses and resistance is almost inevitable. The chemotherapy now available also show important side effects, to overcame those limitation, new platinum-based drugs are being synthetized, Pt(IV)Ac-POA, (OC-6-44)-acetate-diamine-chloride(2-(2-propynyl)octanoato)platinum(IV), a prodrug having an Histone-3-DeAcetylase-Inhibitor as axial ligands, is one of them. Moreover, new compounds of plant origin are increasingly seen as potential sources of benefits in oncological treatments. The aim of the study is to investigate the possible contribution of micotherapy in the fight against GBM, its role in the metabolism of reactive oxygen species (ROS) and its synergic effect with a new platinum-based compound, Pt(IV)Ac-POA, on human glioblastoma U251 cells. Through cytofluorimetric and immunofluorescence analysis, the ability of the micotherapy in study to regulate the cell cycle was assessed, and its importance in controlling the cellular redox state was also revealed, opening to the possibility of a new therapy in which micotherapy can support the activity of new chemotherapy while reducing its side effects controlling inflammatory conditions in the microenvironment. Additionally, the combined therapy appeared able to induce regulated form of necrosis, such as ferroptosis, and to hinder the establishment of resistance mechanisms.
Competing Interests: Conflict of interest The authors declare no competing interests.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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