Peripheral nerve vulnerability as risk factor for multiple sclerosis: Possible insights from Neurofibromatosis type 2 (NF2).

Autor: Schulz A; Institute of Human Genetics, University Hospital Jena, Jena 07747, Germany; Clinician Scientist Program OrganAge, Jena University Hospital, Jena 07747, Germany. Electronic address: alexander.schulz@med.uni-jena.de., McLean ACL; Neurofibromatosis Center, Department of Neurosurgery, Helios Hospital Erfurt, Erfurt 99089, Germany., Rosahl SK; Neurofibromatosis Center, Department of Neurosurgery, Helios Hospital Erfurt, Erfurt 99089, Germany.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2022 Nov; Vol. 67, pp. 104189. Date of Electronic Publication: 2022 Sep 20.
DOI: 10.1016/j.msard.2022.104189
Abstrakt: Despite enormous research efforts, the disease mechanisms causing multiple sclerosis (MS) are still incompletely understood, suggesting a complex and multifaceted pathogenesis. Here, we report the clinical observation that in a designated German center for Neurofibromatosis type 2 (NF2), the number of MS cases among NF2 patients is higher than in the general population. Epidemiological studies investigating a connection between NF2 and MS are difficult to perform due to the rarity of NF2 disease. However, based on the current pathophysiological concepts, we hypothesize that genetically determined vulnerability of peripheral nerves and repeated nerve repair processes might constitute an unrecognized factor to the pathogenesis of MS and might explain the apparent over-representation of MS cases among NF2 patients.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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