Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA study.

Autor:	Martínez Fernández L; Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain. Electronic address: lidiamf87@gmail.com., Sánchez-Alvarez JE; Hospital Universitario de Cabueñes, Gijón, Asturias, Spain; Red de Investigación Renal (REDINREN), Spain., Morís de la Tassa C; Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain., Bande Fernández JJ; Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain., María V; Vascular and Renal Translational, Research Group, Institut de Recerca Biomèdica, Lleida, Spain., Fernández E; Vascular and Renal Translational, Research Group, Institut de Recerca Biomèdica, Lleida, Spain., Valdivielso JM; Vascular and Renal Translational, Research Group, Institut de Recerca Biomèdica, Lleida, Spain., Betriu A; Vascular and Renal Translational, Research Group, Institut de Recerca Biomèdica, Lleida, Spain.
Jazyk:	angličtina
Zdroj:	Nefrologia [Nefrologia (Engl Ed)] 2021 May-Jun; Vol. 41 (3), pp. 337-346. Date of Electronic Publication: 2021 Sep 06.
DOI:	10.1016/j.nefroe.2021.08.002
Abstrakt:	Introduction: Patients with chronic kidney disease (CKD) are at high risk of cardiovascular morbidity and mortality. Subclinical cardiac structural alterations have prognostic value in these patients. The aim was to analyse the prevalence of valvular calcification, the evolution and the relationship with different risk factors. Material and Methods: Part of the sample of the NEFRONA study was randomly selected. Aortic and mitral valve calcification were analysed in echocardiograms performed at the baseline visit and at 24 months. Results: We included 397 patients, the estimated basal glomerular filtrate (eGFR) was 33 ml/min with significant decrease to 30.9 ml/min. There was an increase in the area of carotid and femoral plaque, as well as an increase in patients with aortic and mitral calcification at 24 months. A positive association of mitral calcification at 24 months with age, ankle-brachial index (ABI) and calcium-phosphorus product (CaxP) at baseline visit was observed, without association with eGFR. Aortic calcification at 24 months was positively associated with age, phosphorous and total carotid plaque area at baseline, with no relationship to eGFR. Conclusions: A significant prevalence of valvular calcification was observed in patients with CKD without known cardiovascular disease.Two-year progression was observed independently of the eGFR. Patients with higher risk of mitral valve calcification were those with older age, higher ABI and CaxP product. Patients with a higher risk of aortic calcification were those with older age, higher phosphorous levels and larger area of carotid plaque. Identifying these higher risk patients would help to avoid future cardiovascular events intensifying follow-ups. (Copyright © 2020 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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