Recent approaches in nanocarrier-based therapies for neglected tropical diseases.

Autor: Mengarda AC; Research Center for Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil., Iles B; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília, Distrito Federal, Brazil., Longo JPF; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília, Distrito Federal, Brazil., de Moraes J; Research Center for Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology [Wiley Interdiscip Rev Nanomed Nanobiotechnol] 2023 Mar; Vol. 15 (2), pp. e1852. Date of Electronic Publication: 2022 Sep 25.
DOI: 10.1002/wnan.1852
Abstrakt: Neglected tropical diseases (NTDs) remain major public health problems in developing countries. Reducing the burden of NTDs requires sustained collaborative drug discovery efforts to achieve the goals of the new NTDs roadmap launched by the World Health Organization. Oral drugs are the most convenient choice and usually the safest and least expensive. However, the oral use of some drugs for NTDs treatment has many drawbacks, including toxicity, adverse reactions, drug resistance, drug low solubility, and bioavailability. Since there is an imperative need for novel and more effective drugs to treat the various NTDs, in recent years, several compound-loaded nanoparticles have been prepared with the objective of evaluating their application as an oral drug delivery system for the treatment of NTDs. This review focuses on the various types of nanoparticle drug delivery systems that have been recently used against the major NTDs caused by parasites such as leishmaniasis, Chagas disease, and schistosomiasis. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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