Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women.

Autor:	Silva-Reis A; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Rodrigues Brandao-Rangel MA; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Moraes-Ferreira R; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Gonçalves-Alves TG; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Souza-Palmeira VH; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Aquino-Santos HC; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Bachi ALL; Post-graduation Program in Health Science, University of Santo Amaro, São Paulo, Brazil., de Oliveira LVF; Post-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, Brazil., Lopes-Martins RÁB; Post-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, Brazil., Oliveira-Silva I; Post-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, Brazil., Albertini R; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Frison CR; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil., Vieira RP; Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo, São Paulo, Brazil.; Post-graduation Program in Human Movement and Rehabilitation, Centro Universitário UniEvangélica, Anápolis, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2022 Sep 07; Vol. 13, pp. 946402. Date of Electronic Publication: 2022 Sep 07 (Print Publication: 2022).
DOI:	10.3389/fphys.2022.946402
Abstrakt:	Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown. Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese ( n = 12), overweight ( n = 17), and obese grade I ( n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate. Result: CPE improved forced vital capacity (FVC) % ( p < 0.001) and peak expiratory flow (PEF) % ( p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese ( p < 0.0099), overweight ( p < 0.0005), and obese ( p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese ( p < 0.01), overweight ( p < 0.0009), and obese ( p < 0.0001) groups; resistance of distal airways (R5Hz-R20Hz) in non-obese ( p < 0.01), overweight ( p < 0.0012), and obese ( p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese ( p < 0.01), overweight ( p < 0.0006), and obese ( p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese ( p < 0.0099), overweight ( p < 0.0005), and obese ( p < 0.0001) groups; central resistance (RCentral) in non-obese ( p < 0.01), overweight ( p < 0.001), and obese ( p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese ( p < 0.03), overweight ( p < 0.001), and obese ( p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight ( p < 0.0094) and obese groups ( p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese ( p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight ( p < 0.03) and obese ( p < 0.0001) groups. Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Silva-Reis, Rodrigues Brandao-Rangel, Moraes-Ferreira, Gonçalves-Alves, Souza-Palmeira, Aquino-Santos, Bachi, Oliveira, Lopes-Martins, Oliveira-Silva, Albertini, Frison and Vieira.)
Databáze:	MEDLINE
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