Effect of the ACTN-3 gene polymorphism on functional fitness and executive function of elderly.

Autor:	Henrique JS; Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil., Braga PLG; Department of Psychogerontology, Instituto Educatie de Ensino e Pesquisa, Mogi das Cruzes, Brazil., de Almeida SS; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Department of Physical and Functional Performance, Universidade Ibirapuera, São Paulo, Brazil., Nunes NSP; Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil., Benfato ID; Department of Bioscience, Universidade Federal de São Paulo, Campus Baixada Santista, Santos, Brazil., Arida RM; Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil., de Oliveira CAM; Department of Bioscience, Universidade Federal de São Paulo, Campus Baixada Santista, Santos, Brazil., Gomes da Silva S; Department of Research and Extension, Fundação Cristiano Varella, Muriaé, Brazil.; Centro Universitário FAMINAS, Muriaé, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Sep 09; Vol. 14, pp. 943934. Date of Electronic Publication: 2022 Sep 09 (Print Publication: 2022).
DOI:	10.3389/fnagi.2022.943934
Abstrakt:	During aging, physical integrity and cognitive abilities, especially executive function, become compromised, directly influencing the quality of life of the elderly. One good strategy to ensure healthy aging is the practice of physical exercise. Activities to improve aerobic capacity and muscle strength are extremely important in old age. However, some genetic factors can interfere both positively and negatively with these gains. In this context, the polymorphism rs1815739 (R577X) of the α-actinin 3 gene (ACTN-3) is commonly studied and related to muscle phenotype. Thus, the present study aimed to investigate the effect of the ACTN-3 gene polymorphism on the functional fitness (measured by the Senior Fit test) and cognitive capacity (evaluated by the Stroop test) of the elderly ( n = 347), both men and women. We did not find the effect of genotype on functional fitness, but we did observed a positive effect of the ACTN-3 gene polymorphism on executive function. The presence of the X allele of the ACTN3 gene in the elderly was related to a better performance in the Stroop test (shorter answer time). Our results showed that ACTN-3 gene polymorphism affects the executive function of the elderly but not their functional fitness. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Henrique, Braga, Almeida, Nunes, Benfato, Arida, de Oliveira and Gomes da Silva.)
Databáze:	MEDLINE
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