The bacterial pathogen and resistance spectrum in a dermatological inpatient ward: a six-year, retrospective, epidemiological study.

Autor: Stelzhammer P; Department of Dermatology and Venereology, University Hospital St. Poelten, St. Poelten, Austria.; Karl Landsteiner Institute of Dermatological Research, St. Poelten, Austria., Weber W; Institute for Hygiene and Microbiology, University Hospital St. Poelten, Karl Landsteiner Private University of Health Sciences, St. Poelten, Austria., Binder H; Hospital Pharmacy, University Hospital St. Poelten, St. Poelten, Austria., Sagel U; LADR MVZ Dres. Bachg, Haselhorst & colleagues, Recklinghausen, Germany., Aspöck C; Institute for Hygiene and Microbiology, University Hospital St. Poelten, Karl Landsteiner Private University of Health Sciences, St. Poelten, Austria., Trautinger F; Department of Dermatology and Venereology, University Hospital St. Poelten, St. Poelten, Austria.; Karl Landsteiner Institute of Dermatological Research, St. Poelten, Austria.
Jazyk: angličtina
Zdroj: GMS hygiene and infection control [GMS Hyg Infect Control] 2022 Sep 02; Vol. 17, pp. Doc16. Date of Electronic Publication: 2022 Sep 02 (Print Publication: 2022).
DOI: 10.3205/dgkh000419
Abstrakt: Aim: Treatment of bacterial soft tissue infections is an essential part of clinical dermatology, and the choice of antibiotic therapy is often empirical. The aim of this longitudinal retrospective study was to evaluate bacterial epidemiology, resistance patterns and antibiotic consumption in a dermatological inpatient ward.
Method: Bacterial isolates and antimicrobial susceptibility testing from a dermatological inpatient ward were recorded retrospectively from 2011 to 2016. The antibiotic consumption was evaluated and given as the assumed defined daily dose [DDD] per 100 days of covering per year.
Results: A total of 4,800 bacterial isolates were included (skin, mucous membrane and wounds 87%, urine 9.5%, blood 1.7%, tissue and tissue fluids 1.6%). The proportion of Gram-positive bacteria was 58% ( Staphy loc occus aureus 37.8%, coagulase-negative staphylococci 21.5%, Enterococcus spp . 16.7%). Pseudomonas aeruginosa (27.2%), Escherichia coli (17.5%) and Proteus spp . (13.1%) were the most common Gram-negative bacteria. The proportion of multi-resistant pathogens was 5.8% for methicillin-resistant S. aureus , 0.9%, 0.8% and 1.8% for multi-resis tant P. aeruginosa , ESBL-producing E. coli and E SBL-producing Klebsiella pneumoniae of all isolates. Beta-lactam antibiotics were the most used drugs (14.4, 10.8, and 9.6 DDD/100 for aminopenicillins, cefalexin, and penicillin G), followed by clindamycin (9.0 DDD/100 patient days).
Conclusion: In view of the frequency of bacterial soft tissue infections and their need for inpatient treatment with mostly empirically chosen antibiotics, systematic microbiological surveillance should be recommended for dermatological inpatient wards.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2022 Stelzhammer et al.)
Databáze: MEDLINE
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