Blood parameters and pathological lesions in pigs experimentally infected with Vietnam's first isolated African swine fever virus.

Autor:	Oh SI; National Institute of Animal Science, Rural Development Administration, Wanju, South Korea.; College of Veterinary Medicine, Jeonbuk National University, Iksan, South Korea., Nguyen TTH; Bac Giang Agriculture and Forestry University, Hanoi, Vietnam.; College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam., Yang MS; College of Veterinary Medicine, Jeonbuk National University, Iksan, South Korea., Nga BTT; College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam., Bui VN; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam., Le VP; College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam., Yi SW; National Institute of Animal Science, Rural Development Administration, Wanju, South Korea., Kim E; National Institute of Animal Science, Rural Development Administration, Wanju, South Korea., Hur TY; National Institute of Animal Science, Rural Development Administration, Wanju, South Korea., Lee HS; International Livestock Research Institute, Hanoi, Vietnam.; College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea., Kim B; College of Veterinary Medicine, Jeonbuk National University, Iksan, South Korea.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2022 Sep 08; Vol. 9, pp. 978398. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).
DOI:	10.3389/fvets.2022.978398
Abstrakt:	African swine fever virus (ASFV) is a notable virus and one of the most serious global threats to the pig industry. Improving awareness about host-virus interactions could facilitate the understanding of the disease pathogenesis. Therefore, we investigated changes in blood parameters, viral loads, and pathological changes in ASFV-inoculated pigs according to the time of death after the onset of viremia. For the analyses, the ASFV-infected pigs ( n = 10) were divided into two groups (five pigs/group) according to their time of death after the onset of viremia. The blood cell count dynamics and serum biochemistry profiles were similar between the groups; however, viral load distribution was different. A comparison of the histopathological changes and immunohistochemistry results between the two groups indicated that the lymphoid system, particularly the spleen, was more damaged in the early stage of the disease than in the last stage. Additionally, the virus-induced lesions in other organs (liver and kidney) were more severe in the late stage than in the early stage. Our findings provide invaluable information on the characteristics of blood parameters and pathological lesions in pigs infected with the Asia-epidemic ASFV strain and the course of ASF, targeting internal organs in pigs. Overall, this study characterizes the host-pathogen interaction in ASFV infection, offering insight for the establishment of ASF control strategies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Oh, Nguyen, Yang, Nga, Bui, Le, Yi, Kim, Hur, Lee and Kim.)
Databáze:	MEDLINE
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