[Statins and influenza mortality: systematic review and meta-analysis].

Autor: Masson W; Servicio de Cardiología, Hospital Italiano de Buenos Aires, Argentina., Lobo M; Consejo de Epidemiología y Prevención Cardiovascular, Sociedad Argentina de Cardiología, Argentina., Lavalle-Cobo A; Consejo de Epidemiología y Prevención Cardiovascular, Sociedad Argentina de Cardiología, Argentina., Masson G; Consejo de Epidemiología y Prevención Cardiovascular, Sociedad Argentina de Cardiología, Argentina., Molinero G; Consejo de Epidemiología y Prevención Cardiovascular, Sociedad Argentina de Cardiología, Argentina., Huerín M; Consejo de Epidemiología y Prevención Cardiovascular, Sociedad Argentina de Cardiología, Argentina.
Jazyk: Spanish; Castilian
Zdroj: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia [Rev Chilena Infectol] 2022 Jun; Vol. 39 (3), pp. 321-329.
DOI: 10.4067/s0716-10182022000200321
Abstrakt: Background: Due to their anti-inflammatory properties, it has been suggested that the use of statins could influence the evolution of influenza virus infection.
Aim: To evaluate the effect of statin therapy on mortality from influenza.
Methods: A meta-analysis that included studies evaluating the use of statins in patients with influenza and reporting data on mortality, after searching the PubMed/MEDLINE, Embase, and Cochrane Controlled Trials databases, was performed. A random effects model was applied. The risk of bias was analyzed and a sensitivity analysis was performed.
Results: Eight studies (10 independent cohorts), which included a total of 2,390,730 patients, were identified and eligible for analysis. A total of 1,146,995 subjects analyzed received statins, while 1,243,735 subjects were part of the control group. Statin therapy was associated with lower mortality (OR: 0.66; 95% CI: 0.51-0.85). The sensitivity analysis showed that the results were robust.
Conclusion: Our data suggest that, in a population with influenza, the use of statins was associated with a significant reduction in mortality. These results must be confirmed in future clinical trials.
Databáze: MEDLINE
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