Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.

Autor:	Farag AGA; Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Egypt. Electronic address: azzagaber92@yahoo.com., Labeeb AZ; Microbiology and Immunology Department, Faculty of Medicine, Menoufia University, Egypt., Gerges ANA; Leprosy and Dermatology Clinic, Ministry of Health, Shebin Elkoom Teaching Hospital, Egypt., Elshaib ME; Medical Student, Faculty of Medicine, Menoufia University, Egypt.
Jazyk:	angličtina
Zdroj:	Anais brasileiros de dermatologia [An Bras Dermatol] 2022 Nov-Dec; Vol. 97 (6), pp. 735-741. Date of Electronic Publication: 2022 Sep 21.
DOI:	10.1016/j.abd.2021.09.016
Abstrakt:	Background: Leprosy represents a long-term communicable disease resulting from Mycobacterium leprae infection. IL-17A is one of the pro-inflammatory cytokines that protects humans against many fungal and bacterial pathogens. Objective: To investigate IL-17A (rs2275913) gene polymorphism and its circulating level in leprosy patients, and to correlate the detected results with different clinical aspects of leprosy in the investigated patients. Methods: 60 patients with leprosy, and 29 age and sex-matched volunteers were investigated for IL-17A serum level and IL-17A single nucleotide polymorphism (SNP) by ELISA and RFLP-PCR respectively. Results: IL-17A serum level was significantly higher in leprosy patients than in controls (p=0.034), and in TL than LL (p=0.017). IL-17A (rs2275913 A/G) G allele and GG genotype were associated significantly with LL (p=0.005and 0.001 respectively). IL-17A (rs2275913 A/G) AG genotype carriers demonstrated the highest IL-17A serum levels; however, its lowest levels were found in IL-17A (rs2275913 A/G) AA genotype carriers (p=0.005). Grade 2 disability (p=0.030) and positive slit skin smear (SSS) (p=0.005) were significantly associated with IL-17A (rs2275913 A/G) GG genotype. Study Limitations: The small number of studied subjects. Conclusions: IL -17A may have a pivotal role in leprosy pathogenesis. IL-17A (rs2275913) GG genotype plus G allele might be related to the development of LL in the Egyptian population. (Copyright © 2022. Published by Elsevier España, S.L.U.)
Databáze:	MEDLINE
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