Household transmission of the SARS-CoV-2 Omicron variant in Denmark.

Autor: Lyngse FP; Department of Economics & Center for Economic Behavior and Inequality, University of Copenhagen, Øster Farimagsgade 5, DK-1353, Copenhagen K, Denmark. fpl@econ.ku.dk.; Danish Ministry of Health, Holbergsgade 6, DK-1057, Copenhagen K, Denmark. fpl@econ.ku.dk.; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark. fpl@econ.ku.dk., Mortensen LH; Statistics Denmark, Sejrøgade 11, DK-2100, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1353, Copenhagen K, Denmark., Denwood MJ; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 8, DK-1870, Frederiksberg C, Copenhagen, Denmark., Christiansen LE; Department of Applied Mathematics and Computer Science, Dynamical Systems, Technical University of Denmark, Richard Petersens Plads, 324, DK-2800, Kgs. Lyngby, Denmark., Møller CH; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Skov RL; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Spiess K; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Fomsgaard A; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Lassaunière R; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Rasmussen M; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Stegger M; Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Nielsen C; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Sieber RN; Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Cohen AS; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Møller FT; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Overvad M; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Mølbak K; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 8, DK-1870, Frederiksberg C, Copenhagen, Denmark., Krause TG; Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark., Kirkeby CT; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 8, DK-1870, Frederiksberg C, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Sep 23; Vol. 13 (1), pp. 5573. Date of Electronic Publication: 2022 Sep 23.
DOI: 10.1038/s41467-022-33328-3
Abstrakt: In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.
(© 2022. The Author(s).)
Databáze: MEDLINE
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