Acquired hemophilia A following COVID-19 vaccination - The importance of prompt diagnosis: A case report.

Autor: Duminuco A; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy. Electronic address: andrea.duminuco@gmail.com., Calagna M; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy., Markovic U; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy; Division of Hematology with BMT, Istituto Oncologico del Mediterraneo, Viagrande, Italy; Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy., Esposito B; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy., Grasso S; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy., Riccobene C; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy., Di Raimondo F; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy., Giuffrida G; Division of Hematology with BMT, A.O.U. Policlinico 'G.Rodolico-San Marco', Via S. Sofia 78, 95123 Catania, Italy.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2023 Apr; Vol. 62 (2), pp. 103577. Date of Electronic Publication: 2022 Sep 12.
DOI: 10.1016/j.transci.2022.103577
Abstrakt: Acquired hemophilia A (AHA) is a rare coagulopathy characterized by hemorrhagic manifestations. It has been linked to various conditions, including autoimmune disorders, drugs, tumors, lymphoproliferative disorders, and infections. We present a case of AHA in a 71-year-old male patient with cutaneous hematoma occurring 8 days after vaccination for COVID-19. This report aims to highlight the risk of FVIII inhibitor development following an immune stimulus, thus improving our knowledge regarding possible vaccination-related adverse events. Furthermore, we underline how the potential risk of not recognizing disease manifestations promptly, together with specific coagulation alterations, could significantly affect the patient's outcome. Adequate management plans and the diffusion of shared guidelines are of fundamental importance in order to prevent the development of life-threatening complications and initiate appropriate treatment as soon as possible. DATA AVAILABILITY: All data generated or analyzed during this study are included in this article. Further inquiries can be directed to the corresponding author.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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