Structural and functional state of various parts of skin microcirculation at an early stage of hypertension in working-age men.

Autor: Korolev AI; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia. Electronic address: dr.korolev.andrei@gmail.com., Fedorovich AA; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia; Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshyovskoe sh., 76, building 4, Moscow 123007, Russia., Gorshkov AY; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia., Dadaeva VA; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia; Peoples' Friendship University of Russia, Miklukho-Maklaya str., 6, Moscow 117198, Russia., Omelyanenko KV; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia., Chashchin MG; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia., Drapkina OM; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, building 3, Moscow 101990, Russia.
Jazyk: angličtina
Zdroj: Microvascular research [Microvasc Res] 2023 Jan; Vol. 145, pp. 104440. Date of Electronic Publication: 2022 Sep 20.
DOI: 10.1016/j.mvr.2022.104440
Abstrakt: Study Purpose: To conduct a cross-sectional study on the structural and functional characteristics of various parts of skin microcirculation in working-age men with newly diagnosed hypertension (HTN).
Materials and Methods: The study included 118 male participants (ages 30 to 60) who were not regularly taking any medicine, had no medical complaints, and subjectively considered themselves healthy at the time of study. All participants underwent a cross-sectional comprehensive medical examination. The following tests were performed: complete blood count, biochemical blood tests, video capillaroscopy (VCS), laser Doppler flowmetry (LDF) and photoplethysmography (PPG) on the left hand fingers, determination of flow-mediated vasodilation of the brachial artery, echocardiography, ultrasound of extracranial and femoral arteries, 24-h ambulatory blood pressure monitoring (ABPM). According to ABPM data, the participants were divided into two equal groups called a control group(CG) and a hypertension group(HG). There were 59 participants with normal BP in CG, and 59 participants with newly diagnosed HTN in HG.
Results: Nailfold VCS of the ring finger revealed no significant differences between the groups at the level of exchange microvessels. According to LDF data, there was no decrease in tissue perfusion and signs of an increase in the activity of endothelial, neurogenic, and myogenic regulation of the tone of precapillary arterioles in the HTN group. According to PPG of the index finger, in contrast to CG, HTN participants had significantly higher values of the following parameters: normalized augmentation index (Alp75) - 3.8 % and - 5.25 % (p < 0.005), stiffness index (SI) - 7.6 m/s and 7.35 m/s (p < 0.05), reflection index (RI) - 36.5 % and 28.4 % (p < 0.005), respectively.
Discussion: Working-age men in the early stage of HTN have neither capillary rarefaction nor an increase in the tone of skin precapillary arterioles. The largest contribution to peripheral vascular resistance in the onset of HTN is most likely made by large muscular arterioles, in which the neurogenic regulation of vascular tone predominates.
Competing Interests: Declaration of competing interest The work was carried out within the State Assignment No. 121021100129-2 of the Ministry of Healthcare of Russian Federation. All authors declare no conflict of interest.
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Databáze: MEDLINE