Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients.

Autor: Palomino-Kobayashi LA; Grupo Enfermedades Infecciosas Emergentes. Universidad Científica del Sur, Lima, Peru., Ymaña B; Grupo Enfermedades Infecciosas Emergentes. Universidad Científica del Sur, Lima, Peru., Ruiz J; Grupo Enfermedades Infecciosas Emergentes. Universidad Científica del Sur, Lima, Peru., Mayanga-Herrera A; Laboratorio de Cultivo Celular e Inmunología, Universidad Científica del Sur, Lima, Peru., Ugarte-Gil MF; Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru.; Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru., Pons MJ; Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru.
Jazyk: angličtina
Zdroj: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 06; Vol. 12, pp. 1000291. Date of Electronic Publication: 2022 Sep 06 (Print Publication: 2022).
DOI: 10.3389/fcimb.2022.1000291
Abstrakt: Zonulin has previously been related to intestinal permeability in various inflammatory diseases, and more recently to the physiopathology of severe COVID-19 infections. We analysed serum samples from a previous study of a Peruvian cohort of hospitalised COVID-19 patients, for the quantification of zonulin by sandwich ELISA. Comparisons with clinical data, haematological and biochemical parameters and cytokine/chemokine levels were made. We found higher baseline zonulin levels in deceased patients, and zonulin was associated with fatal outcome in multivariable analyses, even after adjustment for age, gender, and obesity. There were also positive correlations between zonulin, creatinine, D-dimer values and prothrombin time, while inverse correlations were found for Sa/FiO 2 ratio and CCL5 (RANTES). Further longitudinal studies are recommended to analyse the variation of zonulin levels over time as well as their relationship with long-COVID.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Palomino-Kobayashi, Ymaña, Ruiz, Mayanga-Herrera, Ugarte-Gil and Pons.)
Databáze: MEDLINE
Externí odkaz: