Magnitude and predictors of first-line antiretroviral therapy regimen change among HIV infected adults: A retrospective cross sectional study.

Autor:	Alema NM; Department of Pharmacy, College of Medicine and Health Sciences, Adigrat University, Ethiopia., Asgedom SW; Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia., Maru M; Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia., Berihun B; Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia., Gebrehiwet T; Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia., Atey TM; Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia., Demsie DG; Department of Pharmacy, College of Medicine and Health Sciences, Adigrat University, Ethiopia.; Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia., Bantie AT; Department of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Ethiopia., Yehualaw A; Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia., Taferre C; Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia., Seid SA; Department of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Ethiopia., Girma T; Department of Anesthesiology, College of Medicine and Health Sciences, Dilla University, Ethiopia., Allene MD; Department of Anesthesiology, College of Medicine and Health Sciences, Debrebirhan University, Ethiopia., Tamru SM; Department of Anesthesiology, College of Medicine and Health Sciences, Mekelle University, Ethiopia.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2022 Aug 17; Vol. 81, pp. 104303. Date of Electronic Publication: 2022 Aug 17 (Print Publication: 2022).
DOI:	10.1016/j.amsu.2022.104303
Abstrakt:	Background: Regimen change remains a significant challenge towards the achievement of human immunodeficiency virus (HIV) treatment success. In developing countries where limited treatment options are available, strategies are required to ensure the sustainability and durability of the starting regimens. Nevertheless, information regarding the rate and predictors of regimen change is limited in these settings. Objective: This study was undertaken to determine the prevalence and predictors of changes in ART regimens among patients initiating highly active antiretroviral therapy (HAART) at XX. Materials and Methods: An institutional based retrospective cross-sectional study was conducted among adult naïve HIV patients who had initiated HAART at XX between 2010. Data were extracted by reviewing their medical charts using a pretested structured check-list. The Kaplan-Meier survival analyses were used to describe the probability of ARV regimen changes while Cox proportional hazard regression models were employed to identify the predictors of ARV regimen modifications. Data were analyzed using SPSS version 21 software, and statistical significant was deemed at p < 0.05. Results: A total of 770 patients were enrolled in this study of these 165 (21.43%) had their ART regimen modified at least once. Drug toxicity was the main reason for regimen change followed by TB comorbidity, and treatment failure. Positive baseline TB symptoms (aHR = 1.63, p = 0.037), and Zidovudine based regimen (aHR = 1.76, p = 0.011) as compared to Stavudine based regimen were at higher risk of ART modification. Conversely, urban residence, baseline World Health organization (WHO) stage 2 as compared to WHO stage 1, baseline CD4 count ≥301 as compared to CD4 count ≤200 were at lower risk of ART modification. Conclusion: The rate of initial HAART regimen change was found to be high. Thus, less toxic and better tolerated HIV treatment options should be available and used more frequently. Moreover, early detection and initiation of ART by the government is highly demanded to maximize the benefit and reduce risk of ART modifications. (© 2022 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.)
Databáze:	MEDLINE
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