Retrospective Cohort Study of COVID-19 in Patients of the Brazilian Public Health System with SARS-CoV-2 Omicron Variant Infection.

Autor: Murari TB; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil., Fonseca LMDS; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil.; SENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil., Pereira HBB; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil.; Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Salvador 41150-000, BA, Brazil., Nascimento Filho AS; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil., Saba H; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil.; Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Salvador 41150-000, BA, Brazil., Scorza FA; Disciplina de Neurociência, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo 04021-001, SP, Brazil., G de Almeida AC; Departamento de Engenharia de Biossistemas, Universidade Federal de São João del-Rei (UFSJ), São João del-Rei 36307-352, MG, Brazil., Maciel ELN; Laboratório de Epidemiologia, Universidade Federal do Espírito Santo, Vitória 29075-910, ES, Brazil., Mendes JFF; Departamento de Física and I3N, Universidade de Aveiro, 3880 Aveiro, Portugal., Rocha Filho TM; International Center for Condensed Matter Physics and Instituto de Física, Universidade de Brasília, Brasília 70910-900, DF, Brazil., David JR; Faculty of Public Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Department of Immunology and Infectious Diseases, Harvard Medical School, Boston, MA 02115, USA., Badaró R; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil.; SENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil., Machado BAS; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil.; SENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil., Moret MA; Modelagem Computacional, University Center SENAI/CIMATEC, Salvador 41650-010, BA, Brazil.; Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Salvador 41150-000, BA, Brazil.
Jazyk: angličtina
Zdroj: Vaccines [Vaccines (Basel)] 2022 Sep 09; Vol. 10 (9). Date of Electronic Publication: 2022 Sep 09.
DOI: 10.3390/vaccines10091504
Abstrakt: Several vaccines against COVID-19 are now available, based on different techniques and made by different laboratories spread around the world. With the roll out of the vaccination process in an advanced stage in many countries, the reduced risk of hospitalization due to the Omicron variant relative to the Delta variant infection, despite the higher transmission risk of Omicron, may lead to a misinterpretation of the results, as infection by Omicron is associated with a significant reduction in severe outcomes and shorter hospitalization time than the Delta variant. We compared the in-hospital mortality due to the Omicron (Jan-Mar 2022) with Gamma (Jan 2021) and Delta (Oct-Dec 2021) variants of patients in the Brazilian public health system. This study also discusses the decrease in booster vaccine effectiveness in patients hospitalized due to the Omicron variant compared with the Delta variant. Without a remodeling of vaccines for new variants, booster doses may be necessary with a shorter time interval.
Databáze: MEDLINE
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