| Autor: |
McCullough D; Carnegie School of Sport, Leeds Beckett University, Leeds LS6 3QS, UK.; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UK., Harrison T; Department of Clinical Sciences and Nutrition, University of Chester, Chester CH1 4BJ, UK., Boddy LM; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UK., Enright KJ; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UK., Amirabdollahian F; School of Public Health Studies, University of Wolverhampton, Wolverhampton WV1 1LY, UK., Schmidt MA; Advanced Pattern Analysis and Countermeasures Group, Boulder, CO 80302, USA.; Sovaris Aerospace, Boulder, CO 80302, USA., Doenges K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA., Quinn K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA., Reisdorph N; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA., Mazidi M; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Department of Twin Research & Genetic Epidemiology, South Wing St Thomas', King's College London, London SE1 7EH, UK., Lane KE; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UK., Stewart CE; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UK., Davies IG; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UK. |
| Abstrakt: |
High carbohydrate, lower fat (HCLF) diets are recommended to reduce cardiometabolic disease (CMD) but low carbohydrate high fat (LCHF) diets can be just as effective. The effect of LCHF on novel insulin resistance biomarkers and the metabolome has not been fully explored. The aim of this study was to investigate the impact of an ad libitum 8-week LCHF diet compared with a HCLF diet on CMD markers, the metabolome, and insulin resistance markers. n = 16 adults were randomly assigned to either LCHF (n = 8, <50 g CHO p/day) or HCLF diet (n = 8) for 8 weeks. At weeks 0, 4 and 8, participants provided fasted blood samples, measures of body composition, blood pressure and dietary intake. Samples were analysed for markers of cardiometabolic disease and underwent non-targeted metabolomic profiling. Both a LCHF and HCLF diet significantly (p < 0.01) improved fasting insulin, HOMA IR, rQUICKI and leptin/adiponectin ratio (p < 0.05) levels. Metabolomic profiling detected 3489 metabolites with 78 metabolites being differentially regulated, for example, an upregulation in lipid metabolites following the LCHF diet may indicate an increase in lipid transport and oxidation, improving insulin sensitivity. In conclusion, both diets may reduce type 2 diabetes risk albeit, a LCHF diet may enhance insulin sensitivity by increasing lipid oxidation. |
