New Pregnane Glycosides from Mandevilla dardanoi and Their Anti-Inflammatory Activity.

Autor: Lins FSV; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., de Souza TA; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., Opretzka LCF; School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., E Silva JPR; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., Pereira LCO; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., Abreu LS; Department of Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói 24020-150, Rio de Janeiro, Brazil., Pinheiro AAV; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., Dos Santos GLD; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., do Nascimento YM; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., de Melo JIM; Department of Biology, Centre of Biological Sciences and Health, State University of Paraíba, Campina Grande 58429-500, Paraíba, Brazil., Braz-Filho R; Department of Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23851-970, Rio de Janeiro, Brazil., Villarreal CF; School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., da Silva MS; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil., Tavares JF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-90, Paraíba, Brazil.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 14; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 14.
DOI: 10.3390/molecules27185992
Abstrakt: Mandevilla Lindl. is an important genus of the Apocynaceae family, not only as ornamental plants but also for its medicinal uses. In Brazil, Mandevilla species are indicated to treat asthma and skin infections, their anti-inflammatory potential and wound healing properties are also reported in the literature. Concerning their chemical composition, this group of plants is a conspicuous producer of pregnane glycosides. Mandevilla dardanoi is an endemic species from the Brazilian semiarid region not studied by any phytochemical methods. In view of the medicinal potential of Mandevilla species, this study aimed to isolate new pregnane glycosides from M. dardanoi . To achieve this main goal, modern chromatography techniques were employed. Five new pregnane glycosides, dardanols A-E, were isolated from the roots of M. dardanoi by HPLC. Their structures were determined using extensive 1D and 2D-NMR and mass spectrometry (MS n and HRESIMS) data. The cytotoxicity and the anti-inflammatory potential of these compounds were evaluated. The first was evaluated by measuring proinflammatory cytokines and nitric oxide production by stimulated macrophages. Dardanols were able to inhibit the production of nitric oxide and reduce IL-1β and TNF-α. The current work demonstrates the chemodiversity of Brazilian semiarid species and contributes to amplifying knowledge about the biological potential of the Mandevilla genus.
Databáze: MEDLINE
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