Moderate COVID-19: Clinical Trajectories and Predictors of Progression and Outcomes.

Autor: Pappas AG; 1st Department of Critical Care & Pulmonary Service, School of Medicine, Evangelismos General Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece.; COVID-19 Unit, 'Evangelismos' General Hospital, 10676 Athens, Greece., Panagopoulos A; COVID-19 Unit, 'Evangelismos' General Hospital, 10676 Athens, Greece.; 3rd Department of Internal Medicine, 'Evangelismos' General Hospital, 10676 Athens, Greece., Rodopoulou A; COVID-19 Unit, 'Evangelismos' General Hospital, 10676 Athens, Greece., Alexandrou M; 1st Department of Critical Care & Pulmonary Service, School of Medicine, Evangelismos General Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece., Chaliasou AL; COVID-19 Unit, 'Evangelismos' General Hospital, 10676 Athens, Greece.; 4th Department of Internal Medicine, 'Evangelismos' General Hospital, 10676 Athens, Greece., Skianis K; Data Science & Mining Team, École Polytechnique, 91120 Paris, France., Kranidioti E; COVID-19 Unit, 'Evangelismos' General Hospital, 10676 Athens, Greece.; 3rd Department of Internal Medicine, 'Evangelismos' General Hospital, 10676 Athens, Greece., Chaini E; Pulmonary Department, Corfu General Hospital, 49100 Corfu, Greece.; COVID-19 Unit, Corfu General Hospital, 49100 Corfu, Greece., Papanikolaou I; Pulmonary Department, Corfu General Hospital, 49100 Corfu, Greece.; COVID-19 Unit, Corfu General Hospital, 49100 Corfu, Greece., Kalomenidis I; 1st Department of Critical Care & Pulmonary Service, School of Medicine, Evangelismos General Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece.; COVID-19 Unit, 'Evangelismos' General Hospital, 10676 Athens, Greece.
Jazyk: angličtina
Zdroj: Journal of personalized medicine [J Pers Med] 2022 Sep 08; Vol. 12 (9). Date of Electronic Publication: 2022 Sep 08.
DOI: 10.3390/jpm12091472
Abstrakt: Background: Patients with COVID-19 commonly present at healthcare facilities with moderate disease, i.e., pneumonia without a need for oxygen therapy.
Aim: To identify clinical/laboratory characteristics of patients with moderate COVID-19, which could predict disease progression.
Methods: 384 adult patients presented with moderate COVID-19 and admitted to two hospitals were retrospectively evaluated. In a multivariate analysis gender, age, BMI, Charlson Comorbidity Index (CCI) and National Early Weaning Score 2 were treated as co-variates. The development of hypoxemic respiratory failure, intubation rate and risk of death were considered as dependent variables. Estimated values are presented as odds-ratio (OR) with 95% confidence interval (CI).
Results: Most of the patients were male (63.28%) with a mean (standard deviation) age of 59 (16.04) years. Median (interquartile range) CCI was 2 (1-4). A total of 58.85% of the patients developed respiratory failure; 6.51% were intubated, and 8.85% died. The extent of pneumonia in chest X-ray (involvement of all four quartiles) [OR 3.96 (1.18-13.27), p = 0.026], respiratory rate [OR 1.17 (1.05-1.3), p = 0.004], SatO 2 [OR 0.72 (0.58-0.88), p = 0.002], systolic blood pressure [OR 1.02 (1-1.04), p = 0.041] and lymphocyte count [OR 0.9993 (0.9986-0.9999), p = 0.026] at presentation were associated with the development of respiratory failure. The extent of pneumonia [OR 26.49 (1.81-387.18), p = 0.017] was associated with intubation risk. Age [OR 1.14 (1.03-1.26), p = 0.014] and the extent of pneumonia [OR 22.47 (1.59-316.97), p = 0.021] were associated with increased risk of death.
Conclusion: Older age, the extent of pneumonia, tachypnea, lower SatO 2 , higher systolic blood pressure and lymphopenia are associated with dismal outcomes in patients presenting with moderate COVID-19.
Databáze: MEDLINE
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