| Autor: |
Słucznowska-Głabowska S; Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland., Jaworska W; Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland., Staniszewska M; Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland., Tkacz M; Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland., Safranow K; Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland., Łuczkowska K; Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland., Zagrodnik E; Department of Anestesiology, Pomeranian Medical University, 70-111 Szczecin, Poland., Stecewicz I; Department of Pediatrics, Pomeranian Medical University, 70-111 Szczecin, Poland., Machaliński B; Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland., Pawlik A; Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland. |
| Abstrakt: |
Psoriasis is a chronic, proliferative, inflammatory skin disease characterised by skin lesions and systemic symptoms. Numerous cytokines are produced in psoriasis as a result of inflammation. The aim of this study was to examine the plasma concentrations of IL-36α, IL-36β, and IL-37 in psoriasis and their correlations with disease activity parameters. This study recruited 84 individuals, 53 with plaque-type psoriasis and 31 healthy controls. The plaque type of psoriasis is the most common type and is typically characterized by circular-to-oval red plaques distributed over body surfaces of the extremities and scalp. In patients with psoriasis, we observed statistically significantly decreased plasma concentrations of IL-36β and IL-37. The concentrations of IL-36α were increased in comparison with control group. The plasma concentrations of IL-36α and IL-36β were statistically significantly correlated with all tested parameters of disease activity: the Psoriasis Activity Severity Index, Dermatology Life Quality Index, and Body Surface Area Index. There were no statistically significant correlations between plasma levels of IL-37 and the tested parameters of disease activity. These results indicate a role of IL36α, IL-36β, and IL-37 in the pathogenesis of psoriasis. |
