Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

Autor: Surace T; Department of Mental Health and Addiction, Azienda Socio Sanitaria Territoriale Monza, Via G.B, Pergolesi 33, 20900 Monza, Italy., Capuzzi E; Department of Mental Health and Addiction, Azienda Socio Sanitaria Territoriale Monza, Via G.B, Pergolesi 33, 20900 Monza, Italy., Caldiroli A; Department of Mental Health and Addiction, Azienda Socio Sanitaria Territoriale Monza, Via G.B, Pergolesi 33, 20900 Monza, Italy., Ceresa A; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, 20122 Milan, Italy., Esposito CM; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, 20122 Milan, Italy., Auxilia AM; Department of Medicine and Surgery, University of Milano Bicocca, via Cadore 38, 20900 Monza, Italy., Tagliabue I; Department of Medicine and Surgery, University of Milano Bicocca, via Cadore 38, 20900 Monza, Italy., Capellazzi M; Department of Medicine and Surgery, University of Milano Bicocca, via Cadore 38, 20900 Monza, Italy., Legnani F; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, 20122 Milan, Italy., Di Paolo M; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, 20122 Milan, Italy., Cirella L; Healthcare Professionals Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Zanelli Quarantini F; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, 20122 Milan, Italy., Signorelli MS; Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy., Aguglia E; Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy., Clerici M; Department of Mental Health and Addiction, Azienda Socio Sanitaria Territoriale Monza, Via G.B, Pergolesi 33, 20900 Monza, Italy.; Department of Medicine and Surgery, University of Milano Bicocca, via Cadore 38, 20900 Monza, Italy., Buoli M; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, 20122 Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, via F. Sforza 35, 20122 Milan, Italy.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2022 Sep 13; Vol. 12 (9). Date of Electronic Publication: 2022 Sep 13.
DOI: 10.3390/diagnostics12092215
Abstrakt: Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample of bipolar patients.
Methods: A total of 561 patients, consecutively hospitalized for BD in Milan and Monza (Italy), were recruited. Data about the demographic and clinical variables, as well as the values of blood analyses, were collected. The groups identified according to the presence/absence of lifetime suicide attempts were compared using univariate analyses. Then, three preliminary binary logistic regressions and a final logistic regression model were performed to identify the clinical and biochemical parameters associated with lifetime suicide attempts in BD.
Results: Lifetime suicide attempts in BD were predicted by a longer duration of untreated illness (DUI) ( p = 0.005), absence of lifetime psychotic symptoms ( p = 0.025), presence of poly-substance use disorders ( p = 0.033), comorbidity with obesity ( p = 0.022), a last mood episode of manic polarity ( p = 0.044), and lower bilirubin serum levels ( p = 0.002); higher total cholesterol serum levels showed a trend toward statistical significance ( p = 0.058).
Conclusions: BD patients with lifetime suicide attempts present unfavorable clinical features. Some specific biochemical characteristics of bipolar patients may represent potential markers of suicidal behavior and need to be better investigated to identify new targets of treatment in the framework of personalized medicine. These preliminary findings have to be confirmed by further studies in different clinical settings.
Databáze: MEDLINE
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