| Autor: |
Tikhonova NB; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Kuznetsova NB; Center for Stimulation Training, Rostov State Medical University, Ministry of Health of Russia, 344022 Rostov-on-Don, Russia., Milovanov AP; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Goufman EI; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Fokina TV; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Aleksankin AP; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Aleksankina VV; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Stepanova II; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Stepanov AA; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Boltovskaya MN; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Nizyaeva NV; Avtsyn Research Institute of Human Morphology of FSBI 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia. |
| Abstrakt: |
(1) Background: The components of the fibrinolytic system and its main component, plasminogen, play a key role in the first months of pregnancy. The effect of autoantibodies interacting with plasminogen in the formation of retrochorial hematoma is unknown. The aim of our study was to determine the role of plasminogen and IgA, IgM, and IgG, which bind to plasminogen, in retrochorial hematoma. (2) Methods: Prothrombin time (PT), thrombin time (TT), partial activated thromboplastin time (aPTT), soluble fibrin-monomer complex (SFMC), D-dimer, plasminogen activity (%Plg), plasminogen concentration (Plg), and the levels of IgG (IgG-Plg), IgM (IgM-Plg), IgA (IgA-Plg) interacting with plasminogen were determined in plasma samples of 57 women with normal pregnancy and 16 with retrochorial hematoma. (3) Results: %Plg in plasma samples from women with retrochorial hematoma was significantly lower than in plasma samples from women with normal pregnancy. The diagnostic significance of %Plg in the ROC analysis was AUC = 0.85. A direct correlation was found between aPTT and the level of autologous IgM interacting with plasminogen. (4) Conclusions: A decrease in the activity of plasminogen in the blood serum of women in the first trimester of pregnancy may indicate disturbances in the hemostasis system and the formation of retrochorial hematoma. According to the results of the study, it is possible to recommend the determination of plasminogen activity in the management of pregnant women in gynecological practice. |
