Memory CD8 + T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination.

Autor: Brasu N; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Department of Oncology, University of Turin, Turin, Italy., Elia I; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Russo V; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Department of Oncology, University of Turin, Turin, Italy., Montacchiesi G; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Department of Oncology, University of Turin, Turin, Italy., Stabile SA; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., De Intinis C; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Fesi F; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Gizzi K; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Macagno M; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Montone M; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Mussolin B; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Faravelli S; Armenise-Harvard Lab. of Structural Biology Dept. Biology and Biotechnology, University of Pavia, Pavia, Italy., Marchese S; Istituto Nazionale Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy., Forneris F; Armenise-Harvard Lab. of Structural Biology Dept. Biology and Biotechnology, University of Pavia, Pavia, Italy., De Francesco R; Istituto Nazionale Genetica Molecolare 'Romeo ed Enrica Invernizzi', Milan, Italy.; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA., Barnaba V; Pasteur Institute Italy-Fondazione Cenci Bolognetti, Rome, Italy.; Departement Scienze Cliniche, Interistiche, Anestesiologiche e Cardiovascolari, Sapienza University, Rome, Italy., Sottile A; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy., Sapino A; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy.; Department of Medical Sciences, University of Turin, Turin, Italy., Pace L; G. Armenise-Harvard Immune Regulation Unit, IIGM, Candiolo, TO, Italy. luigia.pace@iigm.it.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy. luigia.pace@iigm.it.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2022 Oct; Vol. 23 (10), pp. 1445-1456. Date of Electronic Publication: 2022 Sep 22.
DOI: 10.1038/s41590-022-01313-z
Abstrakt: Understanding immune responses to SARS-CoV-2 messenger RNA (mRNA) vaccines is of great interest, principally because of the poor knowledge about the mechanisms of protection. In the present study, we analyzed longitudinally B cell and T cell memory programs against the spike (S) protein derived from ancestral SARS-CoV-2 (Wuhan-1), B.1.351 (beta), B.1.617.2 (delta) and B.1.1.529 (omicron) variants of concern (VOCs) after immunization with an mRNA-based vaccine (Pfizer). According to the magnitude of humoral responses 3 months after the first dose, we identified high and low responders. Opposite to low responders, high responders were characterized by enhanced antibody-neutralizing activity, increased frequency of central memory T cells and durable S-specific CD8 + T cell responses. Reduced binding antibodies titers combined with long-term specific memory T cells that had distinct polyreactive properties were found associated with subsequent breakthrough with VOCs in low responders. These results have important implications for the design of new vaccines and new strategies for booster follow-up.
(© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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