Incidence of autoantibodies related to systemic autoimmunity in patients with severe COVID-19 admitted to the intensive care unit.

Autor:	Bitzogli K; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, and Institute for Autoimmune Systemic and Neurologic Diseases, Athens, Greece., Jahaj E; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evaggelismos Hospital, Athens, Greece., Bakasis AD; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, and Institute for Autoimmune Systemic and Neurologic Diseases, Athens, Greece., Kapsogeorgou EK; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece., Goules AV; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens; Institute for Autoimmune Systemic and Neurologic Diseases, Athens, and Joint Academic Rheumatology Program, Medical School of the National and Kapodistrian University of Athens, Greece., Stergiou I; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece., Pezoulas V; Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, and Biomedical Research Section, Institute FORTH, Ioannina, Greece., Antoniadou C; Laboratory of Molecular Haematology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Skendros P; Laboratory of Molecular Haematology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Ritis K; Laboratory of Molecular Haematology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Fotiadis DI; Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, and Biomedical Research Section, Institute FORTH, Ioannina, Greece., Kotanidou A; First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evaggelismos Hospital, Athens, Greece., Tzioufas AG; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens; Institute for Autoimmune Systemic and Neurologic Diseases, Athens, and Joint Academic Rheumatology Program, Medical School of the National and Kapodistrian University of Athens, Greece., Vlachoyiannopoulos PG; Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens; Institute for Autoimmune Systemic and Neurologic Diseases, Athens, and Joint Academic Rheumatology Program, Medical School of the National and Kapodistrian University of Athens, Greece. pvlah@med.uoa.gr.
Jazyk:	angličtina
Zdroj:	Clinical and experimental rheumatology [Clin Exp Rheumatol] 2023 May; Vol. 41 (5), pp. 1024-1033. Date of Electronic Publication: 2022 Sep 22.
DOI:	10.55563/clinexprheumatol/2remcx
Abstrakt:	Objectives: To assess the prevalence of autoantibodies (AAbs) in mechanically ventilated COVID-19 patients and to investigate whether AAbs influence the clinical outcome. Methods: Serum samples were drawn within the first 48 hours upon admission to the intensive care unit (ICU) from 217 consecutive patients, from January 1st, 2021, to May 10th, 2021, and investigated for the presence of AAbs using conventional techniques. Serum samples (n=117) of age- and sex-matched healthy individuals collected before COVID-19 pandemic were used as controls. Results: COVID-19 patients in the ICU had more commonly AAbs compared to age- and sex-matched controls (174/217, 80.2% vs. 73/117, 62.4%, p<0.001). Patients expressed more frequently ANAs (48.4% vs. 21.4%, p<0.001), anti-dsDNA (5.1% vs. 0%, p=0.01), anti-CCP (8.3% vs. 1.7%, p=0.014) and anti-CL IgM AAbs (21.7% vs. 9.4%, p=0.005) than controls, respectively. Simultaneous reactivity against at least three autoantigens, occurred in 144 out of 174 (82.8%) patients. The two groups did not differ in terms of clinicoepidemiologic characteristics or the mortality ratio within the ICU. Patients who died compared to convalescents were older, had higher ferritin, D-dimers levels, APACHE II score, lower oxygen saturation, higher prevalence of comorbidities and cognitive dysfunction. However, AAbs were not found to correlate with the clinical outcome. Conclusions: Patients with severe COVID-19 express AAbs more commonly compared to controls. No correlation was found between AAbs and disease outcome.
Databáze:	MEDLINE
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