Optic Neuritis in Multiple Sclerosis-A Review of Molecular Mechanisms Involved in the Degenerative Process.

Autor: Ciapă MA; Emergency Hospital Dimitrie Castroian, 735100 Huși, Romania., Șalaru DL; Cardiology Clinic, Institute of Cardiovascular Diseases, 700503 Iași, Romania.; Department of Internal Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iași, Romania., Stătescu C; Cardiology Clinic, Institute of Cardiovascular Diseases, 700503 Iași, Romania.; Department of Internal Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iași, Romania., Sascău RA; Cardiology Clinic, Institute of Cardiovascular Diseases, 700503 Iași, Romania.; Department of Internal Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iași, Romania., Bogdănici CM; Department of Surgical Specialties (II), University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iași, Romania.; Ophthalmology Clinic, Saint Spiridon Hospital, Iași 700111, Romania.
Jazyk: angličtina
Zdroj: Current issues in molecular biology [Curr Issues Mol Biol] 2022 Sep 02; Vol. 44 (9), pp. 3959-3979. Date of Electronic Publication: 2022 Sep 02.
DOI: 10.3390/cimb44090272
Abstrakt: Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). The emergence and progression of ON in multiple sclerosis is based on various pathophysiological mechanisms, disease progression being secondary to inflammation, demyelination, or axonal degeneration. Early identification of changes associated with axonal degeneration or further investigation of the molecular processes underlying remyelination are current concerns of researchers in the field in view of the associated therapeutic potential. This article aims to review and summarize the scientific literature related to the main molecular mechanisms involved in defining ON as well as to analyze existing data in the literature on remyelination strategies in ON and their impact on long-term prognosis.
Databáze: MEDLINE
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