Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study.

Autor: Ng SP; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA.; Department of Radiation Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Melbourne, VIC 3071, Australia.; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Cardenas CE; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Bahig H; Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada., Elgohari B; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA.; Department of Clinical Oncology and Nuclear Medicine, Mansoura University, Mansoura 35516, Egypt., Wang J; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Johnson JM; Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Moreno AC; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Shah SJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Garden AS; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Phan J; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Gunn GB; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Frank SJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Ding Y; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Na L; Department of Biostatistics, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Yuan Y; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Urbauer D; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Mohamed ASR; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Rosenthal DI; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., Morrison WH; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA., MacManus MP; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Fuller CD; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77098, USA.
Jazyk: angličtina
Zdroj: Current oncology (Toronto, Ont.) [Curr Oncol] 2022 Aug 31; Vol. 29 (9), pp. 6303-6313. Date of Electronic Publication: 2022 Aug 31.
DOI: 10.3390/curroncol29090495
Abstrakt: Background: The PREDICT-HN study aimed to systematically assess the kinetics of imaging MR biomarkers during head and neck radiotherapy. Methods: Patients with intact squamous cell carcinoma of the head and neck were enrolled. Pre-, during, and post-treatment MRI were obtained. Serial GTV and ADC measurements were recorded. The correlation between each feature and the GTV was calculated using Spearman’s correlation coefficient. The linear mixed model was used to evaluate the change in GTV over time. Results: A total of 41 patients completed the study. The majority (76%) had oropharyngeal cancer. A total of 36 patients had intact primary tumours that can be assessed on MRI, and 31 patients had nodal disease with 46 nodes assessed. Median primary GTV (GTVp) size was 14.1cc. The rate of GTVp shrinkage was highest between pre-treatment and week 4. Patients with T3-T4 tumours had a 3.8-fold decrease in GTVp compared to T1-T2 tumours. The ADC values correlated with residual GTVp. The median nodal volume (GTVn) was 12.4cc. No clinical features were found to correlate with GTVn reduction. The overall change in ADC for GTVn from pre-treatment was significant for 35th−95th percentiles in weeks 1−4 (p < 0.001). Conclusion: A discrepancy in the trajectory of ADC between primary and nodal sites suggested that they exhibit different treatment responses and should be analysed separately in future studies.
Databáze: MEDLINE
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